TriNetX at University Hospitals

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UH Research & Education Update | March 2021

By The Clinical Resarch Center Team

TriNetX logo

The UH Clinical Research Center joined the TriNetX network at the end of 2018 to expedite research activities. TriNetX is a global health research network that connects healthcare organizations, biopharmaceutical companies, and contract research organizations. The primary use of TriNetX is to optimize clinical research and access Electronic Medical Record (EMR) data more efficiently. At UH, we have been utilizing TriNetX to query UH patients that meet study inclusion/exclusion criteria to ensure the protocols are feasible before IRB submission. After UH IRB Approval and HIPAA Waivers are in place, we offer generation of patient lists to enhance recruitment in prospective studies and chart reviews through a process called Export ID.

More recently, our team has been working with UH investigators on retrospective de-identified dataset projects using the TriNetX Research Network. The network has data from 48 healthcare organizations across the United States (data from 2011-2021) and we offer free analysis of the datasets for UH investigators. It is important to note that this process is exempt from IRB Review at UH to expedite large network research.

TriNetX De-Identified Research Project Steps include:

  1. Email the Team to set-up initial meeting
  2. Meet with UH TriNetX Support Team to define study population/cohorts
  3. UH TriNetX Support Team will request dataset for the investigators
  4. Investigators send over their specific aims/outcomes for analysis
  5. UH TriNetX Support Team’s Biostatistician will run the analysis on all the data aims/outcomes and input information into manuscript tables for investigators

Note: Steps 3-5 may take up to 2 months for the manuscript to be finalized

We are proud to announce that our team supported a handful of COVID-19 projects utilizing the TriNetX Network which resulted in several 2020 publications led by UH physicians, fellows, and residents. Below you can read about a few of the projects that landed publication:

Pediatric Patients with SARS-CoV-2 Infection: Clinical Characteristics in the United States from a Large Global Health Research Network Ankita Desai, MD, Alexandra Mills, MBA, Sarah Delozier, PhD, Claudia Cabrera Aviles, MD, Amy Edwards, MD, Sahera Dirajlal-Fargo, DO, and Grace McComsey, MD Published on September 12, 2020 in the Cureus Journal

Clinical Characteristics, Hospitalization and Mortality Rates of COVID-19 among Liver Transplant Patients in the United States: A Multi-Center Research Network Study Emad Mansoor, MD, Abe Perez, PhD, Mohannad Abou-Saleh, MD, Seth Sclair, MD, Stanley Cohen, MD, Gregory Cooper, MD, Alexandra Mills, MBA, Kayla Schlick, MS, and Ahmad Kahn, MD Published on September 30, 2020 in the American Gastroenterological Association

Abstract submitted to CROI 2021: Characterizing COVID-19 Presentation and Clinical Outcomes in HIV Patients in the U.S. George A. Yendewa, MD, Jaime Abraham Perez, PhD, Kayla Schlick, MS, Heather Tribout, BS, Grace McComsey, MD

Learn more about TriNetX

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