Wesley Center for Immunotherapy

The Wesley Center for Immunotherapy at UH Seidman Cancer Center

The Wesley Center for Immunotherapy is named in honor of Kimberly and Joseph Wesley, whose $10 million gift supports groundbreaking research to advance life-extending immunotherapies for patients. The Center is a state-of-the-art cellular therapy facility at the forefront of cancer care, where physician-scientists develop CAR T-cell, NK cell, and other cell-based therapies onsite.

The Wesley Center for Immunotherapy is one of only a few nationwide to successfully manufacture CAR T-cell therapy for human use, using a patient’s own immune cells to fight cancer.

At the Wesley Center for Immunotherapy, UH experts are creating cells for CAR T-cell treatment in a rapid one-day manufacturing protocol that can be administered a few days later. This is an improvement over the previous eight-day manufacturing process and vastly different from getting CAR T-cells from a commercial vendor, which can take three to four weeks for a patient’s specifically modified cells to even arrive. This innovation allows UH Seidman Cancer Center physicians to deliver therapy in a timely manner and to more patients than would otherwise be possible. In fact, researchers at UH are developing a CAR-T cell therapy line that will require only standard phlebotomy T-cell collection to produce CAR-T cells, making it possible in the near future to offer CAR T-cell therapy in other locations.

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Cancer cells

From Lab to Life: Expanding the Power of CAR T-Cells

Explore the rapidly evolving world of CAR T-cell therapy and how scientists are reengineering the immune system to fight disease. Drs. David Wald and Reshmi Parameswaran discuss the design, manufacturing, and expanding use beyond blood cancers.

neuron

Breaking Into the Brain: Overcoming Barriers to Understand Autism and Brain Tumors

Matthew Anderson, MD, PhD, and Tyler Miller, MD, PhD, discuss how immune biology is reshaping neuroscience - from autism and obesity to CAR T cell therapies for glioblastoma and the challenge of crossing the blood brain barrier.

CAR T cell therapy in Multiple myeloma (MM) - isometric view 3d illustration.

“Compound A” Could Make Multiple Myeloma More Visible to Naturally Occurring T Cells, UH Seidman Research Suggests

Innovations in Cancer

Tyler Miller, MD standing in front of computer screen with another person sitting in chair looking at image of CAR T scan.

UH Seidman Researcher Parlaying Findings in Nature into More Effective Immunotherapy for Brain Tumors, Targeting Myeloid Cells

Innovations in Cancer

Koen van Besien, MD, PhD

UH Seidman Expert Argues for More Focus on Combination Haplo-Cord Transplant

Innovations in Cancer | January 2025

CAR T cell therapy in UH Wesley Center laboratory

Multiple Myeloma Patients at UH Seidman Cancer Center Have New Immunotherapy Option

BAFF CAR T has important advantage for these patients - Innovations in Cancer | July 2024

Neck cancer illustration

University Hospitals Seidman Cancer Center Launches Biotech Collaboration to Discover Cellular Immunotherapies for Head and Neck Cancer

Innovations in Ear, Nose & Throat | Winter 2023

Getty image lung cancer cell division

UH Seidman Cancer Center at ASH 2022

Innovations in Cancer | Winter 2023