Thoracic & Esophageal Surgery Research

The Division of Thoracic & Esophageal Surgery Engages in Leading-Edge Clinical Research

As a result of our continuing clinical research, the Division of Thoracic & Esophageal Surgery at University Hospitals in Cleveland, Ohio has developed novel surgical techniques and treatments.

In collaboration with Case Western Reserve University School of Medicine, our physicians and researchers conduct ongoing medical studies and clinical trials to determine the most effective treatments for lung disease. In addition, our experts study drugs and the disease progression to find the safest and most effective medicine modalities possible for patients.

Clinical Research Benefits Patients

Some recent research conducted by our team has focused on:

  • Early detection of brochoalveolar carcinoma, a cancer that is increasing in incidence and disproportionately affects non-smokers
  • The use of minimally invasive techniques to treat chest cancers in order to avoid unnecessary surgery
  • Better understanding of organ rejection following lung transplant
  • Long-term survival following lung cancer treatment
  • Use of lobectomy versus sublobar resection for treating small peripheral non-small cell lung cancer

With the hope of leading-edge medical and drug breakthroughs, the Division of Thoracic & Esophageal Surgery offers the opportunity for participation in clinical research trials to any qualified patient. Recent clinical research projects include:

  • A Randomized Phase III Study of Sublobar Resection (+/- Brachytherapy) versus Stereotactic Body Radiation Therapy in High Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC) ACASOG Z4099
  • Genetics and Biological Markers of Lung Cancer
  • MicroRNA Expression in Bronchoalveolar Carcinoma
  • Laser Captures Microdissection and Microarray Analysis of Invasive and Noninvasive Areas of Adenocarcinoma with Bronchoalveolar Carcinoma Features
  • Comparison of Endoscopic Submucosal Dissection versus Mucosal Resection for Neoplasia of the Esophagus, Stomach, Colon, and Rectum
  • Near Infra-Red Spectrophotometry (NIRS)-Based Cerebral Oximetry Monitoring in Elderly Thoracic Surgical Patients Undergoing Single Lung Ventilation Procedures: A Single Center, Prospective, Randomized Controlled Pilot Study Assessing the Clinical Impact of NIRS-Guided Intervention
  • STS Database: Mitigation of lung resection risk through use of limited resection, an analysis of the degree of reduction in lung resection risk when wedge resection, as opposed to lobectomy, is performed.
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