History and Evolution

Foundational Work

Since its inception, the Cardiovascular Phenomics Core has continually evolved to meet the changing needs of cardiovascular research. Historically, the Core served as a leading imaging laboratory, supporting a wide range of studies that relied on advanced invasive and noninvasive imaging technologies.

We led in cardiovascular magnetic resonance imaging (CMRI) endpoints to develop pharmaceutical and biologic therapies, and were the first center in the U.S. to introduce computed tomography (CT)-fractional flow reserve (FFR) technology.

Former Core Imaging Focus

In the past, we served as a core laboratory for numerous studies utilizing a range of imaging modalities. Although this work represented a major focus for many years, similar services are still available on a limited basis.

Invasive: Angiography, Fractional flow reserve (FFR), Intravascular ultrasound (IVUS), Optical coherence tomography (OCT), Quantitative coronary analysis (QCA) and quantitative vascular angiography (QVA)

Noninvasive: Cardiac computed tomography (CCT), Cardiac magnetic resonance imaging (CMRI)

Transition to AI-Driven Phenomics

As research priorities evolved and computational approaches advanced, the Cardiovascular Phenomics Core broadened its mission. The emergence of large-scale datasets, machine learning, and multimodal analysis created new opportunities to examine cardiovascular biology with greater depth and precision.

The Core has since shifted toward an AI-driven phenomics model, integrating imaging, clinical data, and computational tools to support the next generation of cardiovascular research. This evolution builds on our strong imaging foundation while aligning the Core with modern analytical needs and scientific directions.