Heart and Vascular Research

Research and Innovation Center

As part of our mission – To Heal. To Teach. To Discover. – the pillar of research is of tremendous importance at University Hospitals Harrington Heart & Vascular Institute. The innovations brought forward from our research elevate and transform the practice of medicine.

Paving the Way for Next Generation Advances

University Hospitals Harrington Heart & Vascular Institute is home to some of the most innovative research in the United States. Its rich history dates back to the early 20th century when our clinicians pioneered the first surgical treatments of coronary artery disease, the use of defibrillation for resuscitation, and new methods for measuring blood pressure. More recently, our researchers have played an influential role in the pharmacologic control of blood pressure in reducing cardiovascular events, the clinical application of nitrosothiols in cardiovascular disease, highlighting the role of a family of factors termed Kruppel-like factors (KLFs) in diverse biological processes, and demonstrating the importance of environmental factors in the pathogenesis of cardiometabolic disease.

As a nationally recognized integrated model, University Hospitals Harrington Heart & Vascular Institute continues to blaze new trails. Our physician-scientists continually expand their work to encompass all phases of research, from fundamental to clinical and translational studies. The Research and Innovation Center of University Hospitals Harrington Heart & Vascular Institute serves as a unified entity for our specialized units, with streamlined protocols and shared resources like data storage and analytical expertise.

Research Leadership

Mehdi Shishehbor, DO, MPH, PhD

Mehdi Shishehbor, DO, MPH, PhD
President, University Hospitals
Harrington Heart & Vascular Institute

Sanjay Rajagopalan, MD

Sanjay Rajagopalan, MD
Chief Academic and Scientific Officer,
University Hospitals Harrington Heart & Vascular Institute


Clinical Trials Unit (CTU)

The CTU is the largest in the state of the Ohio with over 140 industry sponsored clinical trials following more than 3,500 patients.

Translational Science Unit (TSU)

The TSU facilitates investigator-initiated research and implementation science grants from industry and the National Institutes of Health.

Cardiovascular Biorepository

The Cardiovascular Biorepository is actively engaged in the collection of blood and genomic material for precision medicine initiatives.

Cardiovascular Phenomics Core (CPC)

The CPC leverages expertise, machine learning and artificial intelligence as a repository of techniques and services for both industry and non-industry collaborators.

Vascular Innovation Unit (VIU)

The VIU focuses on cutting edge technologies in limb salvage, bringing technologies to our patients before anywhere else in the world.

Community and Environmental Innovation Core (CEIC)

Fueled by an $18.2 million National Institutes of Health grant, the CEIC focuses on improving cardiovascular outcomes for the underprivileged in Northeast Ohio.

Continuing Medical Education

Grand Rounds