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Heart and Vascular Research

Clinical Trials & Studies

University Hospitals Harrington Heart & Vascular Institute continues to build on a legacy of innovation that began over 150 years ago. Our team is forging medicine’s future by translating cardiovascular advances at the earliest stages of development into improved patient care.

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To learn more about heart and vascular clinical trials, call 216-844-3130

Our team of more than 70 cardiovascular faculty, fellows and staff manages over 140 active clinical trials and follows more than 3,500 patients. Our trials include first-in-human and Phase II-IV studies in cardiovascular medicine, interventional cardiology, electrophysiology, vascular surgery, endovascular therapies, heart failure, cardiac surgery and advanced cardiovascular imaging.

The following highlights just a few of our actively recruiting clinical trials. These and other University Hospitals Cleveland Medical Center advances are poised to benefit the lives of patients affected by heart and vascular diseases for generations to come.

ACHIEVE Greater Cleveland Project

Adiposa Study

Adipose Dysfunction, Imaging, Physiology, and Outcomes with SGLT2i’s for Sleep Apnea


Clinical effectiveness of body fat distribution imaging in real-world practice

Calcium Score

Studies to address risks for cardiovascular disease

Continuous Glucose Monitoring Device Study

Patient Registry Sub-Study Consent: Feasibility and Clinical Utility of the Dexcom in CINEMA Program Patients

with diabetes

Evaluating metabolic mechanisms of Ertugliflozin in diabetes & heart failure

EMMED without diabetes

Evaluating Metabolic Mechanisms of Ertugliflozin in Non-Diabetes Heart Failure with Preserved Ejection Fraction


Evaluation of the GORE® VIAFORT Vascular Stent for Treatment of Symptomatic Iliofemoral Venous Obstruction


Mac-1:GP1b alpha and Immune Activation: Novel Mechanisms of Cardiovascular Events in Systemic Lupus Erythematosus


Registry is to collect safety and performance data on devices used in standard clinical practice


REBIRTH Observational Cohort: Evaluation of Myocardial Recovery in Breastfeeding Women with Peripartum Cardiomyopathy


Study to determine how well a device performs in the treatment of a diseased aortic arch.

Vascular Innovation Unit (VIU)

The Vascular Innovation Unit (VIU) focuses on being the first to bring the latest limb salvage techniques to our patients before anywhere else. Innovative limb salvage clinical trials are underway at University Hospitals Cleveland Medical Center.