Leading the Way in Cystic Fibrosis Research

The Cystic Fibrosis Research Program is extremely active at Case Western Reserve University and University Hospitals Cleveland Medical Center. The central focus of this program resides in the Pediatric Pulmonary Division, but the Research Center includes over 20 investigators in eight departments, including both clinical and basic science departments. The goal for the center is to have a continuum between the basic science work and the final Phase III clinical trials.

Basic Science Research

Learn more about pediatric pulmonology research at Case Western Reserve University and the basic science researchers there who are working diligently toward a cure.

Clinical Research

The Cystic Fibrosis Center is a Translational Therapeutics Development Center in the Therapeutics Development Network, sponsored by the Cystic Fibrosis Foundation. The center has expertise in diagnostic tests and biomarker analysis for both the staging of cystic fibrosis lung disease and for the assessment of interventions for cystic fibrosis lung disease. Magnetic resonance imaging (MRI), multiple breath washout (MBW), infant pulmonary function testing, induced sputum, nasal potential difference, sweat chloride testing, and nasal curettage/brushing are performed through participation in cystic fibrosis studies. The inpatient Dahm’s Clinical Research Unit housed within University Hospitals Rainbow Babies & Children’s Hospital allows us to enroll patients in more complex research studies.

Clinical Trials

We have one of the most active cystic fibrosis clinical trial research programs in the world. At any given time, we have 25-30 active clinical trials ongoing in cystic fibrosis. This provides our patients the opportunity to participate in cutting-edge clinical research. Although we conduct clinical trials in all areas of cystic fibrosis, we have particular expertise in infection and inflammation in the cystic fibrosis lung, treatments aimed at the basic defect in cystic fibrosis, and pancreatic enzyme replacement therapy. Our investigators have led many national and international clinical trials. We have four full-time research coordinators who recruit and enroll patients in trials and conduct the clinical trial visits, three individuals who provide expertise in the regulatory aspects of studies, a dedicated laboratory staff, and a full-time director of the cystic fibrosis processing laboratory and databases. We offer many different clinical trials to our patients and open all of our studies to patients from outside centers. Learn more about our active research studies.

Contact Us

For more information about participation in our cystic fibrosis clinical trials, please contact research coordinators at 216-286-0709.

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