- PACT Methods to Identify and Treat Severe Asthma Patients
Asthma is common but some people don’t respond to traditional treatments. This could be because some asthma patients have high levels of a protein that reduces the amount of a chemical that relaxes airway muscles in their body. This can lead to the airway muscles tightening which can cause symptoms like coughing, wheezing and shortness of breath. There may be drugs that can target this process, but first we must identify which patients have high levels of this protein. We are developing a practical method to do just that.
Project 2Asthma pH Study: Download PDF
It has been shown that acid in the airway affects the body’s response to infection, increases inflammation and affects how well some common medications work. Right now, airway pH can be measured most accurately by a bronchoscopy, a procedure where a camera is inserted into the airway. Our goal is to develop an easier, non-invasive way of measuring pH that can be done in a doctor’s office. This will allow us to use targeted, personalized medicine to treat patients!
The PACT Study is for people with asthma or cystic fibrosis who also:
- Are 18 – 50 years old
- Have had no recent flares
- Have had no recent change in medication- Are available for 3-4 clinic visits over 4-6 weeks
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- PrecISE - Precision Interventions for Severe and/or Exacerbation-Prone Asthma
Severe asthma is different for each person. The PrecISE study is unique because it brings together many types of asthma treatments into one study.
PrecISE is a clinical study sponsored by the National Heart, Lung, and Blood Institute (NHLBI) that uses precision medicine for severe asthma. Precision medicine is an approach to the prevention and treatment of disease that uses information about an individual's or group's specific disease process, symptoms, and treatment responses, to identify the medicines and therapies that are most likely to be effective for them. The two goals of PrecISE are to (1) evaluate exciting new treatments for severe asthma and (2) find patient subgroups for which these treatments work the best.
The PrecISE network consists of leading universities, medical doctors, and scientists dedicated to helping people living with severe asthma. Researchers from over 30 locations across the US, as well as sites in Canada and the UK will recruit adults and teenagers (ages 12 years and older).
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