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Pediatric Nephrology Research

Innovative Research Focused on Improving Treatment and Quality of Life

Leading-edge research is a key component of the Division of Pediatric Nephrology at University Hospitals Rainbow Babies & Children’s Hospital.

Along with Case Western Reserve University School of Medicine, we are investigating the causes, interactions and treatment options related to a variety of pediatric kidney problems. The research includes both clinical trials as well as preclinical (animal) studies.

Investigations Include:

  • The Chronic Kidney Disease in Children (CKiD) Study: This multicenter prospective study follows the course of chronic kidney disease (CKD) progression and its complications in children ages 1 to 18.
  • A Multicenter, Double-Blind, Randomized Study Evaluating De Novo Weekly and Once Every 2 Week Darbepoetin Alfa Dosing for the Correction of Anemia in Pediatric Subjects With Chronic Kidney Disease Receiving and Not Receiving Dialysis: This study is evaluating darbepoetin, a treatment for anemia of CKD in children ages 1 to 17.
  • A Phase 3, Prospective, Randomized, Double-Blind, Placebo-Controlled Multicenter Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Paricalcitol Capsules in Decreasing Serum Intact Parathyroid Hormone Levels in Pediatric Subjects Ages 10 to 16 years with Moderate to Severe Chronic Kidney Disease: This study evaluates the safety and efficacy of paricalcitol capsules as compared to placebo in decreasing serum iPTH in pediatric subjects ages 10 to 16 years with moderate to severe CKD – stages 3 and 4.
  • A Comparative Single-Dose Pharmacokinetic and Safety Study of TAK-491 Between Infants, Children, and Adolescents with Hypertension and Healthy Adults: This is a multicenter, open-label, phase 1 trial of azilsartan medoxomil (TAK-491) in 24 pediatric and eight adult subjects.
  • Targeting Obesity and Blood Pressure in Urban Youth: This school/community-centered study focuses on behavioral interventions to treat obesity and elevated blood pressure in overweight/obese urban youth, grades 6 to 8, in the Cleveland Public School District.
  • Effect of Body Mass Index (BMI) on Exposure-Response Relationships to Lisinopril in Children: This study utilizes ambulatory blood pressure monitoring (ABPM) to diagnose hypertension in children and adolescents and follow the response to lisinopril, a commonly used antihypertensive medication.
  • Magnetic Resonance Imaging (MRI) in Diabetic Nephropathy: This pilot study utilizes novel, quantitative MRI techniques to characterize kidneys in diabetic patients.
  • MRI Imaging Biomarkers of Autosomal Recessive Polycystic Kidney Disease (ARPKD): This study seeks to develop novel, clinically-applicable MRI measures of ARPKD kidney and liver disease to monitor disease progression and response to therapies in an animal model of ARPKD.