Division of Genomic & Molecular Pathology
The Division of Genomic and Molecular Pathology is a subspecialized academic department that provides diagnostic services for University Hospitals Cleveland Medical Center and its associated health system. The Division of Genomic and Molecular Pathology consists of three laboratories that provide a wide range of testing services utilizing a variety of techniques. They include Cytogenetics and Molecular Genetics sections which are located in the W. O. Walker Center 6th floor and the UH Translational Lab is located in Midtown at 7100 Euclid Ave.
- Cytogenetics
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Section Medical Director: Shashi Shetty, PhD
The Cytogenetics Laboratory is a full service laboratory and provides high quality chromosome analysis for prenatal (amniotic fluid, chorionic villi), products of conception, postnatal (peripheral blood, skin fibroblasts), hematology (bone marrow, leukemic blood, lymph nodes), and oncology (solid tumors) applications. Fluorescence in situ Hybridization (FISH) services are offered for a variety of specimen types including prenatal, postnatal, hematologic malignancies and solid tumors. Both paraffin and non-paraffin specimens are accepted.
- Medical Genetics
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Section Medical Director: Thomas Prior, PhD
The Molecular Genetics Laboratory offers a variety of testing using PCR-based methodologies, DNA hybridization, methylation analysis, multiplex ligation-dependent probe amplification (MLPA), chimerism engraftment testing, invader assay, and Sanger sequencing. The full service molecular laboratory offers both clinical testing as well as translational research collaborations.
- University Hospitals Translational Laboratory
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Section Medical Director: Navid Sadri MD, PhD
Bioinformatics Director: David Alouani, PhD
Molecular Pathologist: Jennifer Yoest, MDThe UH Translational Lab provides a variety of next generation sequencing assays for the UH system and other local and regional hospitals. Examples of testing at the UHTL include the identification of molecular findings linked to targeted therapeutic agents and patient prognosis in solid and myeloid malignancies and identification of mutations associated with resistance to HIV antiretroviral therapy.
The UH Translational Lab is also home to a strong group of five bioinformaticians. The group’s main goals involve the analysis of next-generation sequencing data for cancer, germline, virology, and microbiology clinical samples. The group also implements machine-learning algorithms to improve diagnostic accuracy, helps to automate laboratory workflow, and develop platforms for data entry, database query and reporting.