Ongoing Mood Disorder Studies
University Hospitals Department of Psychiatry Research Division’s mission is to conduct clinical research that will not only improve symptom severity, but the quality of life for children and adults suffering from psychiatric illnesses.
Our patient-centered Mood Disorders Program research team is committed to providing compassionate care and education to our patients and their families, while at the same time advancing scientific knowledge. We are dedicated to improving clinical outcomes of under-served patients with mood disorders.
Learn more about our active clinical trials below:
- Brain Circuitry Analysis in Bipolar Disorder
PURPOSE: The purpose of this study is to learn more about how the brain functions in patients with Bipolar Disorder (BD) compared to matched controls. The data collected from this study will then be used to determine if Deep Brain Stimulation (DBS) could possibly be useful in the treatment of BD.
This is an observational study to determine if DBS could be a possible treatment. We hope to one day be able to offer DBS as a standard form of treatment.
ELIGIBILITY: To participate in this study you must be at least 18 years old. You may be eligible if you 1) suffer from Bipolar Disorder, whether or not you are doing well on your current treatment or 2) you have no current or past neurological or psychiatric diagnoses.
Additional criteria will be assessed by a study doctor to determine your eligibility.
PRINCIPAL INVESTIGATOR: Jennifer Sweet, MD
- A 6-Week Randomised, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy of Lurasidone Adjunctive Therapy in Improving Cognitive Functioning in Euthymic Bipolar Disorder Patients (ELICE-BD)
PURPOSE: The purpose of this study is to examine the efficacy of lurasidone for improving cognition in patients with bipolar disorder types I and II who are not experiencing any symptoms of depression or mania, but are still experiencing cognitive impairments (e.g. difficulty with concentration, problem solving, memory etc.). Participants will go through cognitive testing throughout the study to determine efficacy of the medication.
This is the first study we have done looking at cognition in euthymic bipolar patients.
ELIGIBILITY: To participate in this study, you must be between the ages of 19 and 65. You may be eligible if you have bipolar disorder type I or II, and are currently stable on a mood stabilizer but still experiencing problems with cognition. Additional criteria will be assessed by a study doctor to determine your eligibility.
- Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults with Bipolar Disorder and Different Psychiatric Comorbidities: An Eye-Tracking Study
PURPOSE: The overall goal of this study is to assess attentional biases, reward sensitivity, and cognitive control in patients with bipolar disorder with anxiety and/or substance use disorder comorbidity compared to matched controls who do not have any current comorbidities and to utilize this information to determine if eye-tracking technology has a realistic potential of aiding in the diagnosis and treatment of bipolar disorder.
ELIGIBILITY: To participate in this study, you must: be 18 years of age or older; either 1) meet criteria for Bipolar I or II Disorder and are currently depressed or euthymic or 2) have no current or past neurological or psychiatric diagnoses; are not currently taking any steroids, stimulants, or opioid pain killers. Additional criteria will be assessed by a study doctor to determine your eligibility.
- mHealth Study for Individuals with Hypertension and Bipolar Disorder
The purpose of this research is to evaluate a brief, practical adherence intervention (iTAB-CV) delivered via interactive text messaging+ Self-Monitoring (SM) compared to SM alone.
- A Long-Term, Observational, Multi-Center Patient Outcome Registry to Collect Data in Patients for the Scientific Study of Causes, Treatments and Illness Course of Mood Disorders
PURPOSE: This research study is a Registry. A Registry is a collection of information from a set group of patients. No particular treatment is required. The registry will consist of a research database on your demographic information. The purpose of this Registry is to collect demographic information on a wide cross section of patients and to collect information that can be used for future research study recruitment.
ELIGIBILITY: Participants at least 18 years old are needed for a registry study. No particular treatment is required; the registry will consist of a research database of your demographic information, such as name, address, marital status, etc., that can be used for future research study recruitment. If you live in the Cleveland, OH area and are interesting in learning about research opportunities within the Department of Psychiatry at University Hospitals Cleveland Medical Center, you may be eligible. Participants can enroll over the phone or in person. Enrollment will take approximately 30 minutes.
- Risk and Resilience Factors for Combat-Related Posttraumatic Psychopathology and Post Combat Adjustment
The Ohio Army National Guard Mental Health Initiative (OHARNG-MHI) began in 2008 to evaluate the relationships between resilience and risk factors of developing PTSD and other mental illness, and follows soldiers in the Ohio National Guard longitudinally, before, during, and after deployment. The "Risk and Resilience" project is designed to study the relationships between 1) pre-existing mental illness/substance use disorders, 2) deployment to Operation Iraqi Freedom (OIF) or Operation Enduring Freedom (OEF), and 3) post-deployment related mental health and overall psychosocial adjustment.
The study, led by Dr. Joseph Calabrese, recently completed its ninth and final year of data collection. Since the project began in 2008, over 11,300 interviews have been completed with 3,800 Ohio National Guard members.
The project has been able to provide the Ohio National Guard and the community with study related results that will ultimately benefit servicemen and their families. It has been found that: 1) the most common reason individuals stay in the guard is to serve their country, 2) post-deployment social support is an essential factor in the prevention of post-traumatic stress disorder and 3) depression and post-traumatic stress disorder increase the risk of new onset alcohol abuse, during or after deployment.
To date, the study has produced 35 published manuscripts. If you are interested in receiving a list of our published manuscripts, along with a summary of the take home message of each, please e-mail Carla.Conroy@UHhospitals.org.