IgHV Mutational Status Analysis
Chronic Lymphocytic Leukemia (CLL) is the most frequent leukemia in the western world. It affects predominantly elderly individuals. CLL follows a highly variable clinical course. Some individuals diagnosed at an early stage may remain asymptomatic for the rest of their lives; others may progress to aggressive disease over time. Based on the mutational status of the Immunoglobulin Heavy Chain Variable Region Genes (IgHV), CLL patients can be divided into two groups: patients with somatic hypermutations in the IgHV genes usually have longer survival than those without somatic hypermutations. It is believed that IgHV gene mutational status is one of the most robust prognostic markers for CLL patients.
- Determine the mutational status of IgHV genes in patients with Chronic Lymphocytic Leukemia (CLL)
- Adults: 3 – 4 mL whole blood or 2-3 mL bone marrow in purple top EDTA tube
Blood samples stored overnight should be refrigerated or kept cold. Blood samples should never be frozen. Specimens being sent from outside facilities should be packaged with a cold pack according to standard medical safety practices. The specimen should be shipped by overnight priority (scheduled to arrive by Friday AM at the latest).
Center for Human Genetics Laboratory
10524 Euclid Avenue, 6th Floor
Cleveland, OH 44106
For local samples, please call Client Service (216-844-5227) to arrange for sample pick-up.
CPT code (sequence analysis)
Please submit a completed Hematology/Oncology Specimens requisition (PDF) for each sample.