- Harrington Discovery Institute Labs
Mukesh K. Jain, MD
The Jain laboratory identified KLFs as nodal regulators of cardiovascular biology and metabolism. Mukesh K. Jain, MD translated this work and established KLFs as key targets of pharmacologic agents.
Andrew Pieper, MD
The Pieper lab strives to identify and pursue important biological insights into neuropsychiatry, with particular focus on neurodegeneration in disease, injury, and normal aging. The ultimate goal is to improve human brain health through translational basic science leading to new therapies for patients suffering from currently incurable or difficult to treat neuropsychiatric disorders.
Atul Chopra, MD PhD
The Chopra lab focuses its research in the field of energy homeostasis and metabolic disease. Through the assessment of humans with genetic defects in the processing of energy, the lab works to identify new genes and pathways that have escaped attention so far. Its goal is to identify novel processes and paradigms within the realm of energy homeostasis using human and mouse genetics as well as cutting edge molecular biology.
- Ear, Nose & Throat Labs
Kumar Alagramam, PhD
The long-term goal of the Alagramam lab is to understand the genetic program associated with hair cell development and function in the inner ear.. The current focus of Dr. Alagramam's lab is to understand the precise role of Pcdh15 in hair bundle morphogenesis and mechanotransduction.
Martin L. Basch, PhD
The Basch Lab uses mouse embryo as a model system to understand how the inner ear forms. The lab studies how the different cell types in the cochlea interact with each other during embryonic development. The lab goal is to apply the lessons learned from normal development towards regenerative therapies in cases of congenital deafness and age-related hearing loss.
Brian McDermott, PhD
The goals of the McDermott lab is to elucidate the molecular mechanisms of hair-cell development and operation and to determine how these mechanisms relate to human hearing and deafness. The lab is primarily interested in how the genes expressed in the hair cell relate to hair-bundle morphogenesis and operation, hair-cell innervation, and ribbon synapse formation and function. In addition to zebrafish genetics, the McDermott group integrates imaging, physiological, transgenic, and behavioral approaches to study hair-cell development and operation.
Ruben Stepanyan, PhD
The goal of the Stepanyan lab is to study hair cell mechanosensitivity and calcium homeostasis in normal and pathological conditions. Mechanosensitivity of hair cells is necessary for our hearing while calcium is an essential modulator of mechano-electrical transduction.
Qing Yin Zheng, MD
The research in Dr. Zheng’s laboratory focuses on a number of areas in genetics, genomics and proteomics of ear diseases in mice and human. Dr. Zheng established a methodology combining genomics and proteomics to study gene expression in mouse inner ears. The overall aim of the lab studies is to discover genes and molecular pathways that are involved in disease processes in mouse models of human deafness.