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Research Centers

Digestive Health Research Institute

The Case Western Reserve University Digestive Health Research Institute (DHRI) was established under the leadership of inaugural Director, Fabio Cominelli, MD, PhD. The DHRI houses a robust organizational infrastructure capable of supporting and promoting interdisciplinary basic-science, translational and clinical research.

The mission of the Digestive Health Research Institute is threefold:

  1. Ensure a better future for patients struggling with devastating digestive diseases by translating novel basic science discoveries into our clinics.
  2. Expose all levels of trainees to a meaningful research experience with the ultimate goal of promoting enhanced career interest in GI research.
  3. Develop stewards of GI research in the communities we serve through collaboration, resource sharing, and patient care.

The DHRI aims to equip and empower global leaders in digestive disease research and treatment to provide our most valuable stakeholders – patients.


The overarching organizational framework for this Research Center is to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of Barrett’s Esophagus (BE) and Esophageal Adenocarcinoma (EAC). The center also translates laboratory discoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

Cleveland Digestive Diseases Research Core Center

The Cleveland Digestive Disease Research Core Center (DDRCC) is a cross-institutional and multi-disciplinary program between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation. The center’s two major themes are digestive inflammation and metabolism, both of which represent well-established areas of collaborative investigation at CWRU.