Signet Ring Cell Cancer

Signet Ring Cell Cancer

University Hospitals Seidman Cancer Center provides personalized care and the latest treatment options for patients with signet ring cell cancer, a rare but aggressive form of cancer that starts in glandular cells.


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What is Signet Ring Cell Cancer?

Signet ring cell cancer gets its name from the resemblance of the cancer cells to signet rings when viewed under a microscope. This cancer most often develops in the abdominal cavity (the peritoneum), typically in the stomach, although it can start in the colon, rectum, appendix and other organs. When it first appears in the colon, for example, signet ring cell cancer frequently moves through the colonic wall to spread to the peritoneum.

At University Hospitals Seidman Cancer Center, we can diagnose and treat signet ring cell carcinomas in any part of the body. However, the focus of our current research efforts is signet ring cell cancer of the colon, rectum and appendix. About one to two percent of colorectal cancers diagnosed in the U.S. every year are of the signet ring cell variety. Of the approximately 150,000 cases of colorectal cancer diagnosed in the U.S. annually, signet ring cell cancer accounts for about 1,500 to 3,000 cases.


Symptoms of Signet Ring Cell Cancer

Symptoms of signet ring cell cancer often mimic the symptoms of inflammatory bowel disease. Specific symptoms include:

  • Abdominal pain
  • Changes in bowel habits
  • Diarrhea
  • Constipation
  • Rectal bleeding
  • Weight loss

How to Schedule an Appointment

Patients should call our nurse navigator at 216-844-5432 (800-641-2422) to discuss appointment options. New patients will typically meet with the medical oncologist first. Our nurse navigator can work with you to obtain the medical records needed for your visit. The records we ask for include:

  • Note from the medical oncologist (or other cancer doctor) if you have already seen one
  • Biopsy report
  • Imaging results (CT Scans or MRI Scan)
  • Most recent blood work: Comprehensive Metabolic Panel, Complete Blood Count (CBC) and Carcinoembryonic Antigen (CEA) test

International patients should contact the Center for International Relations at 216-844-5657 or cir@UHhospitals.org .


Why Choose UH Seidman Cancer Center for Signet Ring Cell Cancer?

Due to the rarity of signet ring cell cancer, most oncologists have not treated it. At UH Seidman Cancer Center, we have a specialized, comprehensive program devoted to the care of patients with this difficult-to-treat disease. At the heart of the program is a team of fellowship-trained oncologists and surgeons with many years of experience treating signet ring cell cancer.

Patients in our program have access to the latest treatment options, including HIPEC, systemic chemotherapy, radiation therapy and immunotherapy. As a leading cancer research center, UH Seidman Cancer Center supports its signet ring cell cancer care with cutting-edge research into the genomic sequencing and the identification of molecular pathways of the disease in order to develop better therapies.

At UH Seidman Cancer Center, we use leading-edge diagnostics and cancer treatment innovations, such as specialized surgical techniques, systemic chemotherapy, HIPEC, radiation therapy and immunotherapy, to diagnose and treat signet ring cell cancer.

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Signet Ring Cell Cancer Research