Division of Clinical Pathology
The Division of Clinical Pathology provides comprehensive, state-of-the-art, laboratory service across the full spectrum of diagnostic specialties. The Division performs over 16 million tests per year at University Hospitals Cleveland Medical Center which supports the advanced clinical services at UH Cleveland Medical Center, University Hospitals network hospitals, and its broad network of physician practices throughout Northeast Ohio. Both routine and esoteric testing are offered ranging from the highly automated core laboratory to advanced personalized medicine and molecular diagnostics. The Clinical Pathology Division specialty laboratory sections are led by nationally-prominent academic physicians, doctoral scientists, and researchers.
The Division of Clinical Pathology is staffed by over 15 physicians, doctoral scientists, and researchers. Expert consultation on laboratory test selection and interpretation is offered by our medical directors for University Hospitals physicians and providers. The division faculty promotes the research mission of the department through individual and collaborative grants in areas such as drug development, immune function, and analytic laboratory methods.
- Center for Inherited Diseases of Inborn Errors of Metabolism (CIDEM)
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Section Medical Director: Jirair K. Bedoyan, MD, PhD
The Center for Inherited Diseases of Inborn Errors of Metabolism at UH Cleveland Medical Center supports the diagnosis of inherited abnormalities of mitochondrial function including pyruvate metabolism, Krebs cycle, fatty acid metabolism and electron transport chain.
- Clinical Chemistry
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Section Director: Jaime Noguez, PhD, DABCC
The Clinical Chemistry section of the Core Laboratory includes both the Automated Chemistry and Special Chemistry laboratories. The Automated Chemistry section operates 24/7 and employs state-of-the-art automation, sample handling, and analysis for over 7 million routine biochemical tests annually. The Special Chemistry section performs more specialized and esoteric testing to expand the complexity of the chemistry test menu. Testing in these areas includes electrolytes and metabolic profiles, cardiac and lipid markers, hormones, cancer biomarkers, toxicology, and therapeutic drug monitoring. Additionally, enhanced testing for pediatric patients is offered including lead monitoring, biochemical genetics, and cystic fibrosis testing. Expert consultation on laboratory test selection and interpretation is offered by our medical directors for the UHHS physicians and providers.
Center for Inherited Diseases of Inborn Errors of Metabolism (CIDEM)
The Center for Inherited Diseases of Inborn Errors of Metabolism at UH Cleveland Medical Center supports the diagnosis of inherited abnormalities of mitochondrial function including pyruvate metabolism, Krebs cycle, fatty acid metabolism and electron transport chain.
- Diagnostic Immunology
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Section Director: Susan Zhang, MD, PhD
The Diagnostic Immunology laboratory section specializes in the serologic testing for common and complex immunologic disease. This section offers a range of analytic methods including nephelometry, capillary electrophoresis, Enzyme-Linked Immunosorbent Assay (ELISA), Indirect Fluorescent Antibody (IFA), and automated immunoassays. Testing encompasses evaluation and monitoring of infectious disease serology, allergens, autoimmune disease, plasma cell dyscrasias, and immune deficiencies.
- Hematopathology
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Flow Cytometry
Section Medical Director: Howard Meyerson, MD
This section is integral to the complex management of hematological disorders including the Seidman Cancer Center bone marrow transplant program by performing diagnostic immunophenotypic evaluations on a wide variety of hematologic specimens relating to cancer, benign hematology and immunodeficiency states. The section uses multi-color flow cytometers in conjunction with morphology and immunohistochemistry to aid in the diagnosis and management of hematolymphoid diseases.
Hematology/Special Hematology
Section Medical Director: Rose Beck, MD, PhD
This laboratory performs routine hematological testing including complete blood counts and morphological assessments of peripheral blood smears and body fluids and is involved in the evaluation of many hematologic conditions, including anemias, leukemias, and lymphomas, among other disorders.
This section is primarily responsible for tests involved in the evaluation of benign hematologic diseases including the diagnosis and management of hemoglobinopathies, such as sickle cell disease, screening tests for glucose 6-phosphate dehydrogenase deficiency, screening test for fetal gastric hemorrhage and special stains used for the evaluation of hemolysis and leukocytoses. The section also occasionally performs stains used in the evaluation of acute leukemias.
- Histocompatibility and Immunogenetics Laboratory (HIL)
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Section Medical Director: Neil Greenspan, MD, PhD
Associate Section Medical Director: David Wald, MD, PhDThis laboratory provides testing enabling transplantation of solid organs (kidney, liver, heart, pancreas, lung) and hematopoietic cells (bone marrow, blood, cord blood) as well as identification of Human Leukocyte Antigen (HLA) antigens or alleles associated with particular disease states or drug reactions.
- Microbiology
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Interim Section Medical Director: Sree Sarah Cherian, MD
This laboratory offers diagnostic services for bacteriology, virology, mycobacteriology, mycology and parasitology. The lab has been an early adopter of automated technologies including implementation of a new robotic system for bacteriology specimen processing, use of new automated molecular testing systems and application of mass spectroscopy for microorganism identification.
- Molecular Microbiology Diagnostics Laboratory
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Section Medical Director: Lan Zhou MD, PhD
The Molecular Diagnostics Laboratory provides an array of molecular testing – including infectious diseases.
- Point of Care Testing (POCT)
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Section Medical Director: Christine Schmotzer, MD
Medically diagnostic testing at or near the place of patient care can greatly facilitate continuous patient management. The POCT section provides ongoing administrative and logistic support with quality oversight to the multiple clinical services dependent on POCT devices at UH Cleveland Medical Center.
- Transfusion Medicine Service
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Section Medical Director: Katharine Downes, MD
Assistant Medical Director: Robert Maitta MD, PhD
Assistant Medical Director: Hollie Reeves, DOThe Transfusion Medicine-Blood Banking activities including provision of blood and blood components for adult and pediatric transfusion therapy, trauma support, sickle cell disease specialized transfusion support, identification and acquisition of specialized blood and blood components, immunohematology diagnostic testing and evaluation, transfusion reaction investigation, assessment and diagnosis, appropriate blood component utilization, assessment of platelet refractoriness and for granulocyte transfusion therapy, maternal fetal medicine support including intrauterine transfusion, antibody titration assessment, and fetal maternal hemorrhage assessment, Rh Immune Globulin (RhIG) needs, and transfusion support in solid organ and hematopoietic progenitor cell transplantation. Pathologist consultation is available for these activities.
- Blood Bank/Transfusion Medicine
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Section Medical Director: Katherine Downes, MD
Therapeutic Apheresis
Section Medical Director: Robert Maitta, MD, PhD
The Donor Apheresis Center is a part of Transfusion Medicine Services at University Hospitals Cleveland Medical Center and Rainbow, Babies, and Children’s Hospital and its activities center on consultation, management, and performance of autologous and matched related allogeneic hematopoietic progenitor cell donor evaluation and cellular therapy product collection (clinical and research) and therapeutic apheresis. Therapeutic apheresis procedures (automated Red Blood Cell Exchange, Plasma Exchange, Leukodepletion, and Platelet Depletion) are also available. The Donor Apheresis Center is located in the basement of Hanna House.
Coagulation/Special Coagulation
Section Medical Director: Katharine Downes, MD
The Coagulation Laboratories provide comprehensive hemostasis diagnostic testing with both routine and specialized assays for evaluation of bleeding and thrombotic disorders of inherited and acquired conditions and anticoagulant monitoring. Pathologist test interpretation and consultation regarding appropriate test selection is available upon request.