Our world-renowned basic scientists and researchers at University Hospitals Urology Institute, in collaboration with colleagues at the Department of Urology at Case Western Reserve University, are committed to preventing prostate, bladder and renal cancers. One area of focus includes the examination of examining the chemo-preventive properties of green tea in preventing the spread of prostate cancer. Also, we work with a multidisciplinary team of researchers including scientists from the Department of Radiology and UH Seidman Cancer Center, are conducting a comprehensive analysis of bladder cancer. This study focuses on demographic and social determinants of care, mRNA tumor molecular composition, immune histochemical receptor identification, tumor and host-microbiome, and the interaction between host and tumor environment via image analysis algorithm.
The findings from the ongoing studies will quantify functional relevance of tumor and host response, and illuminate the potential relationships between gender and race contributing to disparities in bladder cancer.
Other studies include:
- The implementation and assessment of a patient-centered peri-operative surgical home model approach as a promising, cost-effective strategy at University Hospitals Cleveland Medical Center to reduce post-cystectomy length of stay, ICU transfers, readmissions, control costs, and unnecessary resource utilization through enhanced collaboration and care coordination.
- The assessment of the role of lifestyle, socioeconomic, and neighborhood factors play in potentially impacting molecular features and biological processes in bladder cancer.
- The determination of the prevalence of and potential prognostic value of sex hormone receptor expression in muscle invasive bladder cancer (MIBC).
- A comparison of mRNA expression of hormone-associated pathways between sex and race subgroups.
- The quantification of host immune response via identification of CD8+ tumor infiltrating lymphocytes (TILs) via automatic image analysis (IA) algorithms developed to measure multiple CD8+ phenotypes in formalin fixed paraffin embedded bladder tissue.
- The evaluation of taxonomic and relative bioburden of tumor tissue and distribution of order level phylotype to identify tumor specific distinctive microbiome composition, and assess clinical features of tumor behavior.
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