Our world-renowned basic scientists and researchers at University Hospitals Urology Institute, in collaboration with colleagues at the Department of Urology at Case Western Reserve University, are committed to preventing prostate, bladder, and renal cancers.
Bladder Cancer Research
Our multidisciplinary team of researchers, including scientists from the Department of Radiology and UH Seidman Cancer Center, are conducting a comprehensive analysis of bladder cancer. This study focuses on demographic and social determinants of care, mRNA tumor molecular composition, immune histochemical receptor identification, tumor and host-microbiome, and the interaction between host and tumor environment via image analysis algorithm.
The findings from the ongoing studies will quantify the functional relevance of tumor and host response and illuminate the potential relationships between gender and race contributing to disparities in bladder cancer.
- Bladder Cancer Studies
- Patient-Centered Peri-operative Surgical Home Model: The implementation and assessment of a patient-centered peri-operative surgical home model approach as a promising, cost-effective strategy at University Hospitals Cleveland Medical Center to reduce post-cystectomy length of stay, ICU transfers, readmissions, control costs, and unnecessary resource utilization through enhanced collaboration and care coordination.
- Lifestyle, Socioeconomic & Neighborhood Factors: The assessment of the role of lifestyle, socioeconomic, and neighborhood factors play in potentially impacting molecular features and biological processes in bladder cancer.
- Sex Hormone Receptor Expression: The determination of the prevalence of and potential prognostic value of sex hormone receptor expression in muscle invasive bladder cancer (MIBC).
- mRNA Expression: A comparison of mrna expression of hormone-associated pathways between sex and race subgroups.
- CD8+ Tumor Infiltrating Lymphocytes: The quantification of host immune response via identification of CD8+ tumor infiltrating lymphocytes (tils) via automatic image analysis (IA) algorithms developed to measure multiple CD8+ phenotypes in formalin fixed paraffin embedded bladder tissue.
- Taxonomic & Relative Bioburden of Tumor Tissue: The evaluation of taxonomic and relative bioburden of tumor tissue and distribution of order level phylotype to identify tumor specific distinctive microbiome composition, and assess clinical features of tumor behavior.
Prostate Cancer Research
Our basic science and translational research teams use large data to better diagnose, treat, and understand the biology of prostate cancer.
UH Research & Education Institute Pilot Award
Laura Bukavina, MD, MPH received the UH Research & Education Institute Pilot Award as the Principal Investigator of “Impact of Mental Health Treatment on Bladder Cancer Mortality in US Veterans” study.
Study on Gender Disparity
Researchers at University Hospitals Department of Urology recently published their study on gender disparity in cystectomy postoperative outcomes in the European Urology Oncology Journal.
ASCI's 2021 Young Physician-Scientist Awards
Jonathan E. Shoag, MD is awarded the ASCI's 2021 Young Physician-Scientist Awards (YPSA).
Harnessing clinical data to identify new prostate cancer therapeutics
Jonathan E. Shoag, MD is working to identify drugs that have activity against the normal prostate and can be used to understand and treat prostate cancer.
Medicine’s Jonathan Shoag, MD talks about improved model for prostate cancer screening
Experts urge medical societies to reconsider prostate cancer screening guidelines