Completed Trials and Publications
Stroke
- DAWN Study
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Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN)
Hear from principal investigator Dr. Cathy Sila.
- Read the full publication in The New England Journal of Medicine.
- Navigate ESUS Study
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- Read the full publication in The New England Journal of Medicine.
- Telerehab Study
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Telerehabilitation in the Home versus Therapy In-Clinic for Patients with Stroke
- See the press release on this trial posted on NIH StrokeNet.
- iDEF
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The purpose of this study is to determine whether treatment with the iron chelator, Deferoxamine Mesylate, improves the outcome of patients who have had an intracerebral hemorrhage.
- ROADSTER-2
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This study will evaluate real world usage of the ENROUTE Transcarotid Stent and Transcarotid Neuroprotection System in the management of carotid artery disease.
- SystemCHANGE
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This randomized controlled pilot study will examine the efficacy, feasibility and safety of a health promotion and wellness program in stroke survivors.
- Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)
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The purpose of this NIH-funded study is to determine which of two blood pressure targets is superior in reducing hematoma expansion and improving outcomes after acute intracerebral hemorrhage. Stenting & Angioplasty with Protection in Patients at High Risk for Endarterectomy – Sapphire Registry This industry sponsored registry will determine risks of major adverse events in the treatment of carotid occlusive disease with the Cordis PRECISE® Nitinol Stent System and Cordis ANGIOGUARD™ XP/RX Emboli Capture Guidewire.
- Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS)
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NIH-funded study is to compare the safety and effectiveness of intensive medical therapy plus stenting versus intensive medical therapy only in preventing stroke, heart attacks or death.
- Insulin Resistance Intervention After Stroke Trial (IRIS)
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The purpose of this NIH-funded study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.
- PFO Closure in Cryptogenic Stroke (RESPECT)
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The goal of this industry-sponsored study determines if PFO closure with the AMPLATZER PFO Occluder was superior to the current medical standard of care in the prevention or recurrent embolic stroke in patients with a cryptogenic stroke due to presumed paradoxical embolism.
Neurosurgery
- ACTIsSIMA Study
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This is a controlled study evaluating the stereotactic or minimally invasive injection of SB623 stem cells into the brain of patients with paralysis from a prior ischemic stroke. (Surgical site only – for referrals from recruiting sites).
- EDGE Newton Study
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This multicenter, randomized trial is studying the efficacy and safety of EG-1962 versus the current standard of care with Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage.
- Clazosentan in Reducing Vasospasm-Related Morbidity and All-Cause Mortality in Adult Patients with Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping (CONSCIOUS-2)
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The aim of this industry-sponsored study was to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm-related morbidity and all-cause mortality within 6 weeks post-aSAH treated by surgical clipping.
- Baxter Study
- CLEAR-III
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This study is a multicenter, international, double-blind, randomized study comparing the use of EVD combined with rt-PA against EVD combined with placebo for the treatment of intraventricular hemorrhage.
- Surgical Theater for Acute Stroke Surgical Therapy
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The Surgical Rehearsal Platform allows for pre-operative rehearsal of a planned aneurysm surgery on a computer work station using the patient’s own imaging. The objective of this clinical study is to determine if the use of the Surgery Rehearsal Platform SRP will lead to improved effort and time efficiency in cerebral aneurysm surgery.
- Minimally Invasive Surgery Plus RT=PA For Intracerebral Hemorrhage Evaluation (MISTIE-ICES)
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The purpose of this NIH-funded study is to determine if minimally invasive hematoma evacuation is superior to the current medical standard of care in improving outcomes after hemorrhagic stroke. “Non-invasive Brain-Signal Training to Induce Motor Control Recovery After Stroke” Janis J. Daly, PhD, associate professor of neurology at Case Western Reserve University School of Medicine, was awarded a $1 million EUREKA grant from the National Institutes of Health (NIH) to investigate the feasibility of using Electroencephalography (EEG) signals to direct brain retraining following stroke.
Movement Disorders
- WATCH-PD Trial for patients with Parkinson's disease
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Learn more about the WATCH-PD trial (Wearable Assessments in the Clinic and Home in PD).
This is a study comparing objective, wearable sensors with subjective, clinical examinations of symptoms done by the physician in the office. Additionally, it is comparing the objective sensor information to the patient reports of how they are feeling.
- IMPAX Study
- SURE PD3 for patients with early Study of Urate Elevation in Parkinson’s Disease, Phase 3