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Mehdi Shishehbor, DO, MPH, PhD

Mehdi Shishehbor, DO, MPH, PhD


Cardiology-Vascular Medicine, Cardiology, Cardiology-Interventional Cardiology

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Seeing New Patients As Soon As: Tuesday, Jul 13



  • President, Harrington Heart and Vascular Institute, University Hospitals
  • Director, Interventional Cardiovascular Center, University Hospitals
  • Co-Director, Vascular Center, Harrington Heart and Vascular Institute, University Hospitals
  • Professor, CWRU School of Medicine

Dr. Mehdi H. Shishehbor, DO, MPH, PhD, joined University Hospitals Harrington Heart & Vascular Institute in August 2017 as Co-Chair of the Clinical Executive Committee, Director of the Cardiovascular Interventional Center, and Co-Director of the Vascular Center. His area of expertise includes vascular medicine and minimally invasive, catheter-based procedures such as angioplasty, stent grafts, stenting, atherectomy and intravascular ultrasound to treat coronary, carotid, abdominal aortic aneurysms, and peripheral arterial and venous diseases. He is an expert on minimally invasive approaches to reconstruct lower extremity arteries in order to treat critical limb ischemia and prevent amputation. His work in this area has been recognized locally, nationally and internationally. Prior to joining University Hospitals, Dr. Shishehbor directed the Endovascular Program at the Cleveland Clinic from 2009 to May 2017 and trained over 40 interventional fellows and over 400 physicians nationally on advanced techniques for limb salvage.

Dr. Shishehbor earned his undergraduate degree in chemistry at Florida International University, Miami, followed by a Doctor of Osteopathy (DO) from Nova Southeastern University in Fort Lauderdale, Fla. He completed a Master’s degree in public health at Cleveland State University in 2004 and a doctorate in epidemiology at Case Western Reserve University in 2013.

Following completion of his DO degree, Dr. Shishehbor completed a one-year traditional internship at the Palmetto General Hospital in Hialeah, Fla. He became a resident in internal medicine in 2000 at Cleveland Clinic and was the first internal medicine resident to be granted the Crile Fellowship Award to support a year of basic research in the laboratory of Stanley Hazen, MD, PhD.

Dr. Shishehbor became a clinical fellow in cardiovascular medicine in 2004 and in interventional cardiology in 2007. After completing his interventional cardiology fellowship, Dr. Shishehbor was awarded a sabbatical to train in carotid and aortic endovascular therapy under the mentorship of Bruce Gray, DO, of Greenville, S.C., and Michael Bacharach, MD, with the North Central Heart Institute, Sioux Falls, S.D.

Pursuing his interest in the epidemiology and treatment of cardiovascular disease, Dr. Shishehbor became the first Cleveland Clinic fellow to be awarded the National Institutes of Health KL-2 award. As a National Institutes of Health scholar, Dr. Shishehbor had a joint appointment at Case Western Reserve University and Cleveland Clinic. He is a respected researcher in cardiovascular medicine and has won a number of awards at international and national meetings, including being a research finalist at the American College of Cardiology and the American Heart Association Young Investigator Award competitions. In 2008 he was named the winner of the prestigious Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator award and in 2009 he was awarded the VIVA/LINC Young Leader's Award in Vascular. Currently, he serves as the Co-Chair of the PVD Council for SCAI and as a member of PVD council for the ACC. He was the writing member of 2017 ACC/AHA/SCAI/SVS/SIR Guidelines for Lower Extremity Peripheral Artery Disease and a member of the Appropriate Use Criteria (AUC) committee for renal and peripheral intervention for SCAI in 2017.

Dr. Shishehbor is widely published on cardiovascular epidemiology, interventional cardiology outcomes, and techniques in leading journals such as the Journal of American Medical Association, New England Journal of Medicine, and Journal of the American College of Cardiology and Circulation. He also is the author of a number of editorials, textbook chapters, co-author of a book on coronary intensive care and cardiac catheterization and a manuscript reviewer for several prestigious medical publications, including the Journal of the American Medical Association, Journal of the American College of Cardiology, American Journal of Cardiology, and Archives of Internal Medicine.

As a leader in CLI and limb salvage education he served as the chair of the Masters’ Approach to Critical Limb Ischemia (MAC) Symposium in 2016. Dr. Shishehbor now serves as a Course Director of the Cardiovascular Innovations Conference in Denver.

Dr. Shishehbor’s research interests include clinical outcomes in interventional cardiology, carotid and endovascular interventions. He has a special interest in novel minimally invasive percutaneous approaches to treat cardiac, venous and arterial diseases and has worked with a number of startup companies and early stage devices. An area of intense work has been around perfusion assessment in CLI. He currently has four ongoing prospective studies to evaluate novel perfusion devices in CLI. Additionally he is currently serving as the national principal investigator for five randomized trials related to vascular disease.

He is board certified in internal medicine, cardiovascular medicine, interventional cardiology, vascular medicine, and endovascular/carotid intervention. Dr. Shishehbor is highly involved in family life with his wife and his two children. He was born in Iran, and his wife is from Colombia. He speaks Persian (Farsi) and conversational Spanish. He enjoys cooking, soccer and Persian poetry.


  • Critical Limb Ischemia
  • Peripheral Arterial Disease


Watch to find out more about this University Hospitals provider.

Languages Spoken

English, Farsi, Persian, Spanish

Office Locations

CMC Mather Ste 1500

11100 Euclid Ave
Cleveland OH, 44106

UH Ahuja Medical Center

3999 Richmond Rd
Beachwood OH, 44122

Board Certifications

  • Interventional Cardiology - American Board of Internal Medicine


Fellowship | Endovascular Surgery
Endovascular Surgery - Avera Mckennan Hospital And University Health Center (2009 - 2009)

Fellowship | Endovascular Surgery
Endovascular Surgery - Greenville Hospital System - Greenville Memorial Hospital (2009 - 2009)

Fellowship | Interventional Cardiology
Interventional Cardiology - Cleveland Clinic (2007 - 2009)

Fellowship | Cardiovascular Medicine
Cardiovascular Medicine - Cleveland Clinic (2004 - 2007)

Residency | Internal Medicine
Internal Medicine - Cleveland Clinic (2003 - 2004)

Research Fellowship
Cleveland Clinic (2002 - 2003)

Residency | Internal Medicine
Internal Medicine - Cleveland Clinic (2000 - 2002)

Internship | Rotator
Rotator - Palmetto General Hospital (1999 - 2000)

Other Education | Epidemiology
Epidemiology - Case Western Reserve University (2013)

Other Education
Cleveland State University (2004)

Medical Education
Nova Southeastern University College Of Osteopathic Medicine (1999)

Florida International University (1995)

Industry Relationships

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members’ ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UH’s policy (PDF) on practitioner-industry relationships.

As of December 31, 2016, Mehdi Shishehbor did not disclose any Outside Relationships with Industry.