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Brian Appleby, MD

Brian Appleby, MD



30 Ratings 9 Reviews


Psychiatry, Neurology, Psychiatry-Geriatric Psychiatry

Accepting New Patients

Primary Location

Brain Health and Memory Center
3619 Park East Dr
Suite: 109
Beachwood, OH 44122

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  • Associate Professor of Psychiatry, CWRU School of Medicine
  • Professor of Neurology, CWRU School of Medicine
  • Professor of Psychiatry, CWRU School of Medicine

Brian Appleby, MD is a neuropsychiatrist at University Hospitals Cleveland Medical Center who treats and researches cognitive disorders. Dr. Appleby is an associate professor of neurology, psychiatry, and pathology at Case Western Reserve University and University Hospitals Cleveland Medical Center, the National Prion Disease Pathology Surveillance Center Director, and Medical Director of the Creutzfeldt-Jakob (CJD) Foundation. He is also chair of the Cleveland Chapter Alzheimer's Association Professional Advisory Board.  

Dr. Appleby received his medical degree from Georgetown University School of Medicine. He completed a psychiatry residency at The Johns Hopkins Hospital, where he also completed a geriatric psychiatry fellowship.

His clinical and research interests include prion diseases (e.g., Creutzfeldt-Jakob disease), frontotemporal lobar degeneration, and young-onset dementias.

 In his free time, he enjoys spending time with his family, computers, reading, Taekwondo, and Judo.


  • Behavioral Neurology
  • Creutzfeldt-Jakob Disease
  • Dementia
  • Neuropsychiatry
  • Prion Diseases
  • Young-Onset Dementia


Languages Spoken


Office Locations

Brain Health and Memory Center

3619 Park East Dr
Suite: 109
Beachwood, OH 44122

Patient Experience Reviews

5.0 out of 5

30 Ratings

Patient Comments (9)

Reviewed On 7/1/2023
Dr Appleby and his staff were excellent.

Reviewed On 6/1/2023
Visit was excellent. No complaints

Reviewed On 5/1/2023
Dr Applebee has taken care of *** even before he came to UH. He is easy to talk to and the kind of guy I could have a beer with. He is never worried about the questions I ask about my wife. He has been great support for us over the last 10+ years.

Reviewed On 4/1/2023
Dr Appleby and his staff were excellent. All were very professional and friendly. They spent a great deal of time answering my questions and concerns.

Reviewed On 4/1/2023
I've been fighting serious depression since high school. During that time I've seen many counselors & psychiatrists. Brian Appleby is by far the best. Head & shoulders above anyone else I've ever see.

Reviewed On 3/1/2023
Wonderful Dr Appleby

Reviewed On 1/1/2023
Dr. Appleby was very good. ***

Reviewed On 1/1/2023
Dr Appleby and *** office staff are superior medical professionals.

Reviewed On 12/1/2022
Dr Appleby was the most prepared doctor I've ever seen. He listened to all of my questions and provided responses.

Research & Publications

Research Interests

Prion Disease, Frontotemporal lobar degeneration, Dementia

Certifications & Memberships

  • Geriatric Psychiatry - American Board of Psychiatry and Neurology
  • Psychiatry - American Board of Psychiatry and Neurology
  • Certification in Behavioral Neurology & Neuropsychiatry, United Council for Neurologic Subspecialties


Fellowship | Geriatric Psychiatry
Geriatric Psychiatry - Johns Hopkins Hospital (2007 - 2008)

Residency | Psychiatry
Psychiatry - Johns Hopkins Hospital (2004 - 2007)

Internship | Psychiatry
Psychiatry - Georgetown University Hospital (2003 - 2004)

Medical Education
Georgetown University School Of Medicine (2003)

Goucher College (1999)

Industry Relationships

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members’ ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UH’s policy (PDF) on practitioner-industry relationships.

As of December 31, 2016, Brian Appleby did not disclose any Outside Relationships with Industry.