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Sickle Cell Disease, SCD Biochip

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Sickle Cell Disease (SCD) Biochip: Towards a Simple and Reliable Way to Monitor Sickle Cell Disease.

  • Sex at Birth: Any
  • Age: Child (Birth - 17), Adult (18 - 64), Older Adult (65+)
  • Accepting Healthy People: Yes
  • Type: Others
  • Trial Phase: NA
  • Conditions Being Studied: Sickle Cell Trait

Study Purpose

Sickle-shaped' anemia was first clinically described in the US in 1910, and the mutated heritable sickle hemoglobin molecule was identified in 1949. The pathophysiology of SCD is a consequence of abnormal polymerization of sickle hemoglobin (HbS) and its effects on red cell membrane properties, shape, and density, and subsequent critical changes in inflammatory cell and endothelial cell function. Our goal is to understand the impact of CMA abnormalities in SCD, by interrogating a number of recognized interactions in a range of clinical phenotypes.

Who Can Participate

Age: 1 month and older

Principal Investigator
Amma Owusu-Ansah MD
Department/Division
Hematology/Oncology (Medicine)

Locations

UH Cleveland Medical Center
11100 Euclid Avenue
Cleveland OH, 44106

  • UH IRB: 05-14-07C
  • StudyID: 05-14-07C
  • ClinicalTrials.gov: NCT02824471
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