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Safety, Efficacy, and PK of EVOLVE104 in Advanced Urothelial and Squamous Cell Carcinomas

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A Phase 1 Dose-Escalation and Expansion Study Evaluating the Safety, Efficacy, and Pharmacokinetics of EVOLVE104 in Subjects With Advanced Urothelial and Squamous Cell Carcinomas

  • Sex: Any
  • Age: Adult (18 - 64), Older Adult (65+)
  • Accepting Healthy People: No
  • Type: Interventional / Therapeutic
  • Trial Phase: Phase I
  • Conditions Being Studied: Cancer - Urethral

Study Purpose

The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have been ineligible for treatment with these medications. Participants with advanced or metastatic cancer who meet all eligibility criteria may be eligible to participate in the study.

Principal Investigator
Jameel Muzaffar MD
Department/Division
Cancer (Genitourinary)
  • UH IRB: STUDY20260496
  • StudyID: EVIM1Y26
  • ClinicalTrials.gov: NCT07217171
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