S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

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Phase 1 Study of S-Nitrosylation Therapy to Improve Tissue Oxygenation During Autologous Blood Transfusion in Healthy Volunteer

Sex: Any
Age: Adult (18 - 64)
Accepting Healthy People: Yes
Type: Interventional / Therapeutic
Trial Phase: Phase I
Conditions Being Studied:

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Study Purpose

The purpose of the study is to find out whether giving adults an experimental drug called ethyl nitrite (ENO) can improve oxygen delivery to the body's tissues during a blood transfusion.

Who Can Participate

Healthy volunteers between 18 and 35 years of age that are considered eligible by American Red Cross standards to donate blood may be eligible for this study. Participants will be screened by qualified practitioners for eligibility to receive either saline or your own blood back.

Principal Investigator
Mada Helou MD

Department/Division
Anesthesiology (Institute of Transformative Molecular Medicine)

Locations

UH Cleveland Medical Center
11100 Euclid Avenue
Cleveland OH, 44106

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UH IRB: STUDY20221492
StudyID: 2023-01145
ClinicalTrials.gov: NCT03999229

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