Investigational Treatment Therapy to Reduce Graft-Versus-Host Disease in Acute Myelogenous Leukemia Patients

Study Purpose

The goal of this clinical trial is to see if adding abatacept to tacrolimus and MMF prevents or reduces the chances of acute graft versus host disease which is a complication that can occur after transplant in participants with blood cancer. The usual therapy for graft versus host disease prevention after a cord blood transplant includes tacrolimus and MMF. The main question this clinical trial aims to answer is whether or not abatacept will be safe and effective in reducing aGVHD rates in dCBT. Participants will: - Partake in exams, tests, and procedures as part of usual cancer care. - Partake in conditioning, which is the treatment that is given before a transplant. - Have a cord blood transplant. - Partake in radiation following the transplant.