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Centessa 7063148

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A Phase 2a, Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ORX750 in Subjects with Narcolepsy and Idiopathic Hypersomnia – (CRYSTAL-1)

Sex:
Age: Adult (18 - 64)
Accepting Healthy People: No
Type: Interventional / Therapeutic
Trial Phase: Phase II
Conditions Being Studied: Idiopathic Hypersomnia, Narcolepsy

Study Purpose

The main purpose of this study is to learn how safe and tolerable ORX750 is compared with placebo as a possible treatment for sleep-wake disorders, such as narcolepsy and idiopathic hypersomnia.

Who Can Participate

Age: 18 - 65 years old

Principal Investigator
Sally Ibrahim MD

Department/Division
Pediatrics (Pulmonology)

Locations

UH Cleveland Medical Center
11100 Euclid Ave
Cleveland OH, 44106

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UH Beachwood Medical Center
25501 Chagrin Blvd
Beachwood OH, 44122

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UH Parma Medical Center
7007 Powers Blvd
Parma OH, 44129

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UH IRB: STUDY20250430
StudyID: 2025-01685
ClinicalTrials.gov: N/A

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