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AZD8205 vs Physician's Choice of Chemo in B7-H4-Selected Advanced/Metastatic Endometrial Cancer

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4 Selected Advanced/Metastatic Endometrial Cancer Who Progressed On or After Platinum Based Chemotherapy and Anti-PD-1/Anti-PD-L1 Therapy (Bluestar-Endometrial01)

Sex: Female
Age: Adult (18 - 64), Older Adult (65+)
Accepting Healthy People: No
Type: Interventional / Therapeutic
Trial Phase: Phase I
Conditions Being Studied: Cancer – Endometrial

Study Purpose

This is a Phase III, 2-arm, randomized, open label, multicenter, global study assessing the efficacy and safety of puxitatug samrotecan compared to physician's choice of chemotherapy (doxorubicin or paclitaxel) in participants with B7-H4 selected advanced/metastatic EC that progressed following platinum based chemotherapy and anti-PD-1/anti-PD-L1 therapy.

Principal Investigator
Amy Armstrong MD

Department/Division
Cancer (Gynecological)

UH IRB: STUDY20251126/Pro00090013
StudyID: ZNCA3825
ClinicalTrials.gov: NCT07044336

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