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(212Pb)Pb-DOTAM-MAM279 in small cell lung cancer and other DLL3 expressing solid tumors

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A Phase 1/2a Study to Assess Safety, Tolerability, and Efficacy of [212Pb]Pb-DOTAM-MAM279 in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

Sex: Any
Age: Adult (18 - 64), Older Adult (65+)
Accepting Healthy People: No
Type: Interventional / Therapeutic
Trial Phase: Phase I
Conditions Being Studied: Cancer - Solid Tumor

Study Purpose

The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of [212Pb]Pb-MP0712, in patients aged ≥18 years with Small Cell Lung Cancer and other locally advanced or metastatic DLL3 positive tumors.

Principal Investigator
Afshin Dowlati MD

Department/Division
Cancer (Any Solid Tumor)

UH IRB: STUDY20251630
StudyID: MLPN1Y25
ClinicalTrials.gov: NCT07278479

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