Clinical Trials

The Vision Research Coordinating Center (VRCC) is a joint collaboration between the UH Eye Institute and the CWRU Department of Ophthalmology and Visual Sciences. The center was established in 2004 to coordinate all ophthalmic clinical trials contracted through UH or CWRU. Descriptions of some of the current clinical trials are listed below, categorized by area:

Contact Lens

1-Day Acuvue® Tru-Eye™ Brand Contact Lenses & 1-Day Acuvue® Moist® Brand Contact Lenses with LACREON® TECHNOLOGY Daily Disposable Performance Registry – TEMPO Study – currently enrolling

PI: Loretta Szczotka-Flynn, OD, Ph.D
Sponsor: Johnson & Johnson
Coordinator: Sangeetha Raghupathy
216-844-8552

Infiltrative Events During Silicone Hydrogel Daily Contact Lenses (DWCIE – Daily-Wear Corneal Infiltration Event) – enrollment closed

PI: Loretta Szczotka-Flynn, OD, Ph.D
Sponsor: Alcon
Coordinator: Sangeetha Raghupathy
216-844-8552

A Prospective, Randomized, Open Label Clinical Trial on the Association Between Mucin Balls and the Development of Corneal Infiltrative Events During ExtendedWear with Silicone Hydrogel Contact Lenses – currently enrolling

PI: Loretta Szczotka-Flynn, OD, Ph.D
Sponsor: Vistakon, Johnson & Johnson
Coordinator: Sangeetha Raghupathy
216-844-8552

Role of Mucin in Contact Lens-Induced Corneal Infiltrates – enrollment closed

PI: Loretta Szczotka-Flynn, OD, Ph.D
Sponsor: Vistakon
Coordinator: Sangeetha Raghupathy
216-844-8552

Pediatric Ophthalmology

A Pilot Study to Determine Feasibility of Non-Invasive Measurement of Retinal Blood Flow in Severe Low Birth Weight Infants (LDF4ROP) – enrollment to begin Summer 2012

PI: Suber S. Huang, MD, MBA
Sponsor: UH/CWRU/NASA
Coordinator: Cherie Hornsby, RN
216-844-7408

Other

Analysis of Intraocular and Serum Cholesterol Profiles in Patients Undergoing Cataract Surgery: A Pilot Study – currently enrolling

PI: Irina Pikuleva, Ph.D
Sponsor: Ophthalmology Dept.
Coordinator: Nyesha Smith
216-983-5254

Therapeutic Effects of Cataract Removal in Alzheimer’s disease – currently enrolling

PI: Grover C. Gilmore, Ph.D
Sponsor: NIH.
Coordinator: Tatiana Riedel
216-368-6465

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