Article Summary Summer 2012

NI Journal, Volume 5 • Number 1 • Summer 2012

Editorial: The Case Brain Health Collaborative

By Anthony J. Furlan, MD

The 2008 – 2013 strategic plan for Case Western Reserve University (Case) created four interdisciplinary alliances, including one for Human Health. Each alliance represents an interdisciplinary priority identified by Case as an area of current or potential strength in research and scholarship that involves faculty and students across multiple disciplines and that addresses topics of broad importance to society.

New Therapeutics for Alzheimer Disease: Targeting Nuclear Receptors to Modify Disease Pathogenesis

By Gary Landreth, PhD

Alzheimer disease (AD) represents the largest unmet medical need. Unless therapeutic interventions are found, AD will exact a devastating toll on health care systems throughout the world.

Translational Research of Age-Related Neurodegenerative Disorders

By Jiri G. Safar, MD

Prion diseases, originally called transmissible spongiform encephalopathies, are invariably fatal neurodegenerative diseases that affect humans and animals.

Setting a New Default for Brain Health Using fMRI

By Anthony I. Jack, PhD

Amidst the excitement generated by startling new images of the brain in action, President George H.W. Bush (1989-1993) declared the 1990s the decade of the brain.

Network Analysis Decoded: Using Category Fluency as a Model System for Network Analysis

By Alan J. Lerner, MD

There is a long tradition of seeing the organization of body parts as similar to man-made devices. Thus we see comparisons made between the function of the eye and a camera.

Brain Health – A Global Perspective

By Anthony Randal McIntosh, PhD

The somewhat ambitious title of this paper is meant to convey two things. First, it’s a framework for me to present an overview of the approach we are taking at Baycrest Centre at the University of Toronto to address the global challenges of brain health in an aging population. Many demographic studies are emphasizing the impending “aging tsunami,” and we have positioned our programs at Baycrest to deal with it. Second, the idea of a global perspective can be considered in the sense that the brain itself is a collection of networks and part of a large system in the body wherein consideration of the interdependence of the brain and body will lead to new perspectives on preserving and improving brain health.

Integrating Brain Health into Wellness: The Importance of Technology and Exercise

By Anitha Rao-Frisch, MD and Peter Whitehouse, MD, PhD

Decline in cognition is a concern for individuals and societies as the world’s population continues to age. Innovative health systems are recognizing the significance of an integrated approach to health care, aiming for total-body as well as total-mind wellness.

Taking Brain Health to a Deeper and Broader Level

By Peter Whitehouse, MD, PhD

Of the many people who sell brain health potions or programs, most have it wrong or at least incomplete.

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