American Society of Hematology Presentations

CWRU/SCC PRESENTATIONS AND DISCUSSIONS

Saturday, December 10

Clark Distelhorst, MD
Speaker, Scientific Program: (Dys-) Regulation of Cell Metabolism in Lymphoid Neoplasia
Saturday, December 10, 2011, 4:00 PM-5:30 PM
Room 6A (San Diego Convention Center)
“Autophagy and Metabolism in Lymphoid Malignancies”

Monday, December 12

Hillard M. Lazarus, MD FACP
Moderator, Oral and Poster Abstracts: Clinical Allogeneic Transplantation - Conditioning Regimens, Engraftment and Acute Transplant Toxicities: Acute Transplant Toxicities
Monday, December 12, 2011, 10:30 AM-12:00 PM
Douglas Pavilion B (Manchester Grand Hyatt San Diego)

Tuesday, December 13

Cheng-Kui Qu, MD, PhD
Moderator, Oral and Poster Abstracts: Hematopoiesis - Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Cell Signaling and Transcriptional Regulation of Stem Cells and Progenitors
Tuesday, December 13, 2011, 7:30 AM-9:00 AM
Marriott Hall 5-6 (San Diego Marriott Marquis & Marina)

Alvin H. Schmaier, MD
Moderator, Hemostasis and Thrombosis Program: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion
Tuesday, December 13, 2011, 12:00 PM-1:30 PM
Room 25 (San Diego Convention Center)

POSTER PRESENTATIONS

Saturday, December 10

“Characterization of Hematopoietic Stem Cell Function and Sensitivity in the Homologous Recombination Deficient Exonuclease1mut Mouse Model”
Poster Session: Hematopoietic Stem and Progenitor Biology: Poster I
Saturday, December 10, 2011, 5:30 PM-7:30 PM
Hall GH (San Diego Convention Center) ;
Authors: Amar Desai, Yulan Qing, PhD and Stanton L. Gerson, MD

“Effects of Enhanced Physical Activity on Hematopoietic Stem Cell Aging in PEPCK-Cmus Transgenic Mice”
Poster Session: Hematopoietic Stem and Progenitor Biology: Poster I
Saturday, December 10, 2011, 5:30 PM-7:30 PM
Hall GH (San Diego Convention Center)
Authors: William W. Qu, Parvin Hakimi, Nathan A. Berger and Richard W. Hanson

“Human Mesenchymal Stem Cells Attenuate Graft-Versus-Host Disease and Maintain Graft-Versus-Leukemia in Murine Allogeneic Bone Marrow Transplantation”
Oral and Poster Abstracts: Experimental Transplantation - Immune Function, GVHD and Graft-versus-Tumor Effects: Posters I
Saturday, December 10, 2011, 5:30 PM-7:30 PM
Hall GH (San Diego Convention Center)
Authors: Jeffery J Auletta, MD, Saada Eid, BS, Matthew Keller, BS, Leland Metheny, MD, Rocio Guardia-Wolff, BS,Zhenghong Lee, PhD, Luis A Solchaga, PhD and Kenneth R. Cooke, MD

“Prophylaxis of Acute Gvhd Using Stromal Cell Therapy: Preliminary Results After Administration of Single or Multiple Doses of Multistem® in a Phase I Trial”
Oral and Poster Abstracts: Clinical Allogeneic Transplantation - Acute and Chronic GVHD, Immune Reconstitution: Poster I
Saturday, December 10, 2011, 5:30 PM-7:30 PM
Hall GH (San Diego Convention Center)
Authors: Richard T. Maziarz, MD, Timothy deVos, MD, Carlos Bachier, MD, Steven C. Goldstein, MD, Jose F. Leis, MD, PhD, Robert Perry, BS, Robert Deans, PhD, Wouter J Van't Hof, PhD and Hillard M. Lazarus, MD

“BEP Versus BEAM Conditioning for Autologous Hematopoietic Cell Transplantation in Relapsed Lymphoma. A Single Center Retrospective Review of Two Contemporaneous Cohorts”
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation-Results: Poster I
Saturday, December 10, 2011, 5:30 PM-7:30 PM
Hall GH (San Diego Convention Center)
Authors: Paolo F. Caimi, MD, Ashley Rosko, MD, Pingfu Fu, PhD, Huda S. Salman, MD, Tamila L. Kindwall-Keller, DO,Brenda W. Cooper, MD and Hillard M. Lazarus, MD FACP

Sunday, December 11

“Thrombin Modulates PAR1-PAR4 Heterodimers”
Oral and Poster Abstracts: Platelet Activation and Biochemistry: Poster II
Sunday, December 11, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Maria de la Fuente, Amal Arachiche, PhD and Marvin T. Nieman, PhD

“The Impact of Obesity on the Presentation & Outcome of Adult Acute Myeloid Leukemia (AML) - ECOG Studies E1900 & E3999”
Oral and Poster Abstracts: Acute Myeloid Leukemia - Biology and Pathophysiology: Poster II
Sunday, December 11, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: James M. Foran, MD, FRCPC, Zhuoxin Sun, PhD, Hugo F. Fernandez, MD, Larry D Cripe, MD, Rhett P Ketterling, MD, Janis Racevskis, PhD, Selina M. Luger, MD, Elisabeth Paietta, PhD, Hillard M. Lazarus, MD, FACP, Mark R. Litzow, MD and Martin S. Tallman, MD

“Charlson Comorbidity Index (CCI) Not Hematopoietic Cell Transplantation Specific-Comorbidity Index (HCT-CI) Successfully Predicts Transplant Related Mortality and Post-Transplant Outcomes in Elderly Patients Undergoing Reduced Intensity Conditioning (RIC) Umbilical Cord Blood (UCB) TransplantationClinically Relevant Abstract” Oral and Poster Abstracts: Clinical Allogeneic Transplantation
Conditioning Regimens, Engraftment and Acute Transplant Toxicities: Acute Transplant Toxicities: Poster II
Sunday, December 11, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Tamila L. Kindwall-Keller, DO, Mary J. Laughlin, MD, Pingfu Fu, PhD, Hillard M. Lazarus, MD FACP, Paolo F. Caimi, MD, Cynthia Owusu, MD, Merle J. Kolk, Richard J. Creger, Pharm D, Huda S. Salman, MD, Stanton L. Gerson, MD, Kenneth R. Cooke, MD and Brenda W. Cooper, MD

“Allogeneic Hematopoietic Cell Transplantation (HCT) for Neuroblastoma (NB): The CIBMTR Experience”
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation-Results: Poster II
Sunday, December 11, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Gregory A. Hale, MD, Stephan A Grupp, MD, PhD, Kimberly A. Kasow, DO, Michael R. Bishop, MD, Menachem Bitan, MD, PhD, Richard Childs, MD, Edward A. Copelan, MD, Mitchell S. Cairo, MD, Bruce Camitta, MD, Ka Wah Chan, MD, MBBS, Stella M. Davies, MBBS, PhD, Miguel A. Diaz, MD, John J Doyle, MD, Robert Peter Gale, MD, PhD, DSc, Vicent M. Gonzalez, MD, Biljana N. Horn, MD, Sonata Jodele, MD, Naynesh R. Kamani, MD, Hillard M. Lazarus, MD, FACP, Victor A. Lewis, MD, Kasiani C. Myers, MD, Michael A. Pulsipher, MD, Muna Qayed, MD, MSc, Jean Sanders, MD, Peter J. Shaw, MA, MB, BS, MRCP, FRACP, Sandeep Soni, MBBS, Edward A. Stadtmauer, MD, Patrick Stiff, MD, Donna A. Wall, MD and Mukta Arora, MD

“Is There a Role for ASCT in Patients with Desmoplastic Small Round Cell Tumor of the Peritoneum?”
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation-Results: Poster II
Sunday, December 11, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Rachel J Cook, MD, MS, Zhiwei Wang, MS, Mukta Arora, MD, Hillard M. Lazarus, MD, Kimberly A. Kasow, DO, Martin A. Champagne, MD, FRCPC, Wael Saber, MD, MS, Koen M. Van Besien, MD, Gregory A. Hale, MD, Edward A. Copelan, MD, Mohamed Elmongy, MD, DSc, Naoto T Ueno, MD, Biljana N. Horn, MD, Shimon Slavin, MD and Edward A. Stadtmauer, MD

Monday, December 12

“A CIBMTR Prognostic Model for Progression-Free Survival (PFS) After Autologous Hematopoietic Cell Transplantation (AHCT) for Relapsed or Refractory Hodgkin Lymphoma (HL)”
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation - Results: Lymphoma and Multiple Myeloma
Monday, December 12, 2011, 10:30 AM
Douglas Pavilion C (Manchester Grand Hyatt San Diego)
Authors: Theresa Hahn, PhD, Philip L. McCarthy Jr., MD, Jeanette Carreras, MPH, Mei-Jie Zhang, PhD, Hillard M. Lazarus, MD FACP, Ginna G. Laport, MD, Silvia Montoto, MD, David G. Maloney, MD, PhD and Parameswaran Hari, MBBS, MD, MRCP

“Factor XII Promotes Leukocyte Inflammation and Its Deficiency Results in Faster Wound Healing”
Oral and Poster Abstracts: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion: Endothelium, von Willebrand factor, and Blood Coagulation
Monday, December 12, 2011, 10:45 AM
Marriott Hall 4 (San Diego Marriott Marquis & Marina)
Authors: Evi Stavrou, MD, Gretchen A. LaRusch, Matthew J. Fullana, Gary E. Wnek, Cheng-Kui Qu, Wen-Mei Yu,Howard J. Meyerson, Chao Fang, Nicholas P. Ziats and Alvin H. Schmaier, MD

“Non-Lineage/Stage Restricted Effects of a Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn11 (Shp2) on Malignant Transformation of Hematopoietic Cells”
Oral and Poster Abstracts: Hematopoiesis - Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Growth and Survival Signaling in Normal and Leukemic Hematopoietic Cells
Monday, December 12, 2011, 10:45 AM
Room 24 (San Diego Convention Center)
Authors: Dan Xu, Xia Liu, Wen-Mei Yu, Howard J. Meyerson, Stanton L. Gerson, MD and Cheng-Kui Qu

“Over-Expression of the Mas Receptor Decreases Arterial Thrombosis Risk in B2R KO Mice by Elevating NO and Prostacyclin and Reducing GPVI Activation”
Oral and Poster Abstracts: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion: Endothelial Receptors and Signalling
Monday, December 12, 2011, 5:15 PM
Marriott Hall 4 (San Diego Marriott Marquis & Marina)
Authors: Chao Fang, Evi Stavrou, MD, Alec A Schmaier, PhD, Gregory N Adams, Marvin T. Nieman, PhD, Gretchen LaRusch, Matthew Bilodeau, MD, PhD, Fakhri Mahdi, Mark Warnock and Alvin H. Schmaier, MD

“KLF2 and KLF4 Are Essential Mediators of the Anti-Thrombotic Effects of Statins in the Presence of Antiphospholipid/Anti-ß2GPI Antibodies”
Oral and Poster Abstracts: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion: Poster III
Monday, December 12, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Kristi L Allen, PhD, Mukesh K Jain, MD and Keith R. McCrae, MD

“Young Adults Presenting with Extramedullary Acute Myeloid Leukemia Have A Unique Sensitivity to High Doses of Anthracyclines: Subset Analysis of ECOG 1900”
Oral and Poster Abstracts: Acute Myeloid Leukemia - Therapy, excluding Transplantation: Poster III
Monday, December 12, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Hugo F. Fernandez, MD, Zhuoxin Sun, PhD, Mark R. Litzow, MD, Selina M. Luger, MD, Elisabeth Paietta, PhD, Janis Racevskis, PhD, Gordon W. Dewald, PhD, PhD, FACMG, Rhett P Ketterling, MD, John M. Bennett, MD, Jacob M. Rowe, MD, Hillard M. Lazarus, MD, FACP and Martin S. Tallman, MD

“Regulatory-Approval Driven Safety and Efficacy of MGMTP140K Lentivirus Transduction of Human CD34+ Cells for a Phase I Clinical Trial for Upfront Treatment of Glioma”
Oral and Poster Abstracts: Gene Therapy and Transfer: Poster III
Monday, December 12, 2011, 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
Authors: Yulan Qing, PhD, Jane Reese, Min Liu, Amar Desai, Heather Embree, Boro Dropulic, MBA, PhD and Stanton L. Gerson, MD

Tuesday, December 13

“Reduced Intensity or Non-Ablative Hematopoietic Cell Transplantation in Older Patients with Non-Hodgkin Lymphoma (NHL): Encouraging Survival for Patients ≥55 Years”
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation - Results: Allogeneic Hematopoietic Stem Cell Transplantation (conditioning regimen)
Tuesday, December 13, 2011, 7:30 AM
Douglas Pavilion B (Manchester Grand Hyatt San Diego)
Authors: Brian McClune, DO, Tanya L. Pedersen, MPH, Kwang W Ahn, PhD, Erica D Warlick, MD, Joseph Pidala, MD, MS, Edmund K Waller, MD PhD, J. Douglas Rizzo, MD MS, Mitchell S. Cairo, MD, Ann Woolfrey, MD, Andrew Artz, MD MS, Hillard M. Lazarus, MD FACP and Daniel J. Weisdorf, MD

“Cell of Origin Determination in Diffuse Large B-Cell Lymphoma: Performance of Immunohistochemical (IHC) Algorithms and Ability to Predict Outcome”
Oral and Poster Abstracts: Non-Hodgkin Lymphoma - Biology, excluding Therapy: Clinical Determinants and Microenvironment
Tuesday, December 13, 2011, 7:45 AM
Room 5AB (San Diego Convention Center) 
Authors: Brian T. Hill, MD, PhD, Angela M.B. Collie, MD,PhD, Tomas Radivoyevitch, PhD, Eric D. Hsi, MD and John Sweetenham, MD

“Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1α Dependent and Independent Pathways”
Oral and Poster Abstracts: Hematopoietic Stem and Progenitor Biology: Pluripotent Stem Cells, Reprogramming and Differentiation
Tuesday, December 13, 2011, 8:45 AM
San Diego Ballroom AB (San Diego Marriott Marquis & Marina)
Authors: Jinwei Du, Yu Chen, Qiang Li, Zhengqi Wang, Sally Dunwoodie, Kevin D. Bunting, PhD and Yu-Chung Yang, PhD

“Prolylcarboxypeptidase Promotes Endothelial Cell Proliferation and Vascular Repair”
Poster Session: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion
Tuesday, December 13, 2011, 12:00 PM-1:30 PM
Room 25 (San Diego Convention Center)
Authors: Gregory N Adams, Gretchen LaRusch and Alvin H. Schmaier, MD

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