Clinical Research

Research, Advancing the Care of Children with Endocrine Disorders

Advanced research on children’s diabetes, growth disorders, obesity and other endocrine conditions is conducted at University Hospitals Rainbow Babies and Children’s Hospital.

The Division of Endocrinology, Diabetes & Metabolism through its affiliation with Case Western Reserve University School of Medicine has received millions of dollars annually from the National Institutes of Health (NIH) and other funding organizations. It is one of the largest research programs of its kind.

From molecular research to genetics, clinical studies, policy research, and up-to-the-minute diabetes studies, research being conducted here is advancing children’s health. Our researchers are bringing new tools to physicians treating children. Some of the studies we are working on include:

  • Epidemiology of Diabetes Interventions and Complications (EDIC): EDIC consists of examining the development of complications as the result of glucose control for diabetes. The study includes an investigation of genetics related to those complications. Case Western Reserve University School of Medicine and University Hospitals Rainbow Babies & Children’s Hospital are the national clinical coordinating centers for the study.
  • Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY): TODAY is a landmark National Institutes of Health study of over 700 children and adolescents with type 2 diabetes, which is on the rise along with childhood obesity rates. Case Western Reserve University School of Medicine and UH Rainbow Babies & Children’s Hospital are among 13 sites selected to participate.
  • Understanding the relationship between cystic fibrosis and diabetes: UH Rainbow Babies & Children’s Hospital is also leading the way in studying diabetes with roots in cystic fibrosis. About 30 percent of children with cystic fibrosis will develop a unique kind of diabetes. The division received an award from the Cystic Fibrosis Foundation to develop a special clinic to gather data and treat more children with the condition.
  • Continuous glucose monitoring in young adults with diabetes: Clinical researchers are examining the potential for advanced continuous glucose monitoring systems to improve outcomes for children with diabetes.
  • Growth disorders: Clinical research explores how to best treat children with short stature of various causes.
  • Obesity: UH Rainbow Babies & Children’s Hospital conducts a number of programs focusing on the prevention and treatment of obesity and other chronic conditions.

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