Clinical Research

University Hospitals Leads Clinical Research Studies Exploring Neuromuscular Diseases

Advanced research and clinical trials are a key component of the Neuromuscular Center’s mission at University Hospitals Neurological Institute. Our physician-researchers are involved in a variety of investigations, each with the potential to improve diagnosis and treatment. Our physicians and scientists contribute to:

  • ICE PAC NIH Grant (Interstitial Cystitis Evaluation of Psychophysiologic and Autonomic Characteristics): To understand the role of the nervous system in this debilitating chronic pain disorder, as well as in another pelvic pain disorder called myofascial pelvic pain syndrome.

MUSK Study for patients with myasthenia gravis

We are currently enrolling in the MSK-002 trial (“A Randomized, Placebo-Controlled, Parallel Group Study to Evaluate the Effect of Amifampridine Phosphate in Patients with MuSK Antibody Positive Myasthenia Gravis, and a Sample of AChR Antibody Positive Myasthenia Gravis Patients”). This is a study for patients with a condition called myasthenia gravis, specifically those who are not getting effective benefit or are not tolerating their medication for the disease. The purpose of the study is to learn about the safety and effectiveness of a drug called amifampridine phosphate. This drug has not been approved by the U.S. FDA, but it has been approved to treat an autoimmune disorder in the European Union.

You may qualify for this study if:

  • You are 18 years of age or older
  • You have a documented and confirmed diagnosis of myasthenia gravis
  • You are not taking certain medicines that might interfere with the study drug or procedures
  • Your doses of certain medications are stable and will not interfere with study drug or procedures

**(Your medications will be reviewed by the study doctor and study team to confirm safety and eligibility)

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