Research and Clinical Trials For Alzheimer's Disease & Memory Disorders
Experts from the Brain Health & Memory Center at University Hospitals Neurological Institute are dedicated to studying and developing promising therapies in the field of brain health, cognition, and memory disorders. Our team of physicians and scientists work closely to conduct research and clinical trials to better understand and care for patients affected by these disorders.
Please see the list of current clinical trials below. If you would like more information about any of the research studies, please complete the information form at the bottom of the page or call 216-453-0778.
- APT Webstudy
We are now enrolling in the Alzheimer Prevention Trials Webstudy (APT Webstudy) and helping in the fight against Alzheimer’s. The APT Webstudy, which is an online memory and thinking research study aiming to accelerate enrollment into Alzheimer’s clinical trials. Participants will have their memory assessed every 3 months and will be tracked over time, all online. It’s easy and at no cost. If it is found that you are at increased risk for developing Alzheimer’s, you may be invited for an in-person evaluation that may include additional memory tests, brain scans and blood tests.
You may qualify for this study if you are:
- Age 50 and older
If you, a family member, or a friend would like to learn more about joining the Alzheimer Prevention Trials Webstudy, please visit the APT Webstudy website.
- Alzheimer’s Disease Neuroimaging Initiative (ADNI)
ADNI, is a historic study of brain aging looking to help change the future. ADNI’s unprecedented approach to research is intended to encourage new investigation and to increase the pace of discovery in the race to prevent, treat and one day cure Alzheimer’s disease.
You may be able to help if you are 55 to 90 years of age and:
- Are in good general health
- Are cognitively normal, have Mild Cognitive Impairment (MCI) or have been diagnosed with mild dementia due to Alzheimer's
- Are willing and able to undergo in-clinic assessments, memory testing and other test procedures
- Have a study partner who can accompany you to all clinic visits
- Are fluent in English or Spanish
- A Proof-of-Concept Clinical Research Study of Efavirenz in Patients with Alzheimer’s Disease
The purpose of this study is to examine the effects of the drug Efavirenz on humans with mild cognitive impairment or dementia due to Alzheimer's disease to see if it will produce changes in brain cholesterol, as it has in animal models. This study is being done because research has shown that high levels of cholesterol in the brain are associated with a higher risk of developing Alzheimer’s disease. Patients will be enrolled in the study for 22 weeks, and will have about 8 visits and 5 phone calls over this time.
You may qualify for this study if:
- You are ages 55-85 years old
- You have been diagnosed with Alzheimer’s disease
- The Cleveland Alzheimer’s Disease Research Center (CADRC)
The Cleveland Alzheimer’s Disease Research Center (CADRC) is a National Institute of Aging Center which has the goal of increasing the speed of research being done on aging-related brain disorders. A key activity of the CADRC is a multi-site, observational study in which older individuals both with and without dementia will be followed over time. Participants will be asked to undergo bio-specimen collection, imaging procedures, and cognitive testing on an annual basis. This readily-available data will be used to advance national-level future research, including therapeutic trials.
You may qualify for this study if you are:
- Age 18 and older
- Clinical research study for patients with a variety of neurodegenerative disorders
We are currently enrolling in a clinical research study for patients with a variety of neurodegenerative disorders. Some neurodegenerative parkinsonisms are difficult to diagnose in the early stage of the disease. Skin biopsy could be a useful way to diagnose and measure the severity of these conditions. The purpose of the study is to identify changes on a punch skin biopsy, which are small pieces of skin removed and sent to the laboratory for examination. Your participation will last between 1 and 2 years and will include between 2 and 4 visits. Visits will include a physical exam, questionnaires, a memory test, a punch skin biopsy, and blood draw. We will also be looking to enroll patients to serve as “controls,” who do not have any neurological illness.
You may qualify if:
- You are 18-89 years old
- You have a diagnosis of any of the following: Parkinson’s Disease, multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy, corticobasal degeneration
- You are not taking warfarin or other “anticoagulation” blood thinners
- You do not have any other progressive neurological condition
Some past and current research projects include:
- Study to assess the effectiveness of Troriluzole to protect against or slow down memory and thinking problems in those with mild to moderate Alzheimer's Disease
- Drug studies in Alzheimer’s disease and frontotemporal dementia
- Multiple studies of the genetics of Alzheimer’s disease
- A study designed to determine the effect of cataract surgery on the Alzheimer patient’s quality of life, vision and cognition
- A study that examines how brain imaging technology can help measure the progression of mild cognitive impairment (MCI) and early Alzheimer’s disease
- Studies evaluating the safety and effectiveness of Dimebon in patients with mild to moderate Alzheimer's disease on donepezil (Aricept)
- Studies of depression in caregivers of Alzheimer’s disease patients
- Assessment of caregiving methods and outcomes
- Studies of the genetics of Alzheimer’s disease
We are located at:
3619 Park East Drive, Suite 211
Beachwood, OH 44122