Eye Image Reading Centers

The Eye Image Reading Centers’ mission is to provide superior image analysis and trial development support for clinical trials and studies examining the effects of drugs, devices and diseases on the cornea and the retina.

The Eye Image Reading Centers at University Hospitals Eye Institute and Case Western Reserve University comprises two of the leading ophthalmic image analysis centers:

Established at University Hospitals Cleveland Medical Center and Case Western Reserve University, the two eye image reading centers have extensive experience with multicenter, national and international, federal and corporate-sponsored clinical trials. Our standardized protocols ensure rapid and consistent analyses, while our technical expertise results in refined acquisition, training and analysis techniques. This technical expertise is enhanced by significant medical director involvement in study design to ensure the highest quality and limit inconsistencies.

The Eye Image Reading Centers are governed by the University Hospitals Institutional Review Board, which is fully accredited by the Association for the Accreditation of Human Research Protection Programs. Our staff follows the regulations set forth by Good Clinical Practices, International Conference on Harmonization, Department of Health and Human Services, and Food and Drug Administration regulations.

Our work with nationally recognized principal investigators, contract research organizations, federal agencies and large pharmaceuticals allows us to tailor our analyses toward improved anatomic and body composition data while maintaining scientific integrity.

Our Services

We provide image analysis for a variety of ophthalmic diseases, including:

  • Diabetic macular edema
  • Fuchs' dystrophy
  • Glaucoma
  • Neovascular and non-neovascular macular degeneration
  • Neuro-ophthalmological diseases
  • Uveitis
  • Vitreoretinal interface disorders

We also evaluate corneal endothelial safety and toxicity related to devices in the anterior chamber, corneal and intraocular surgery and viscoelastics; and retinal safety related to intravitreal medications. Additionally, the center grades ocular images for safety studies of drugs used in nonophthalmological studies.

We offer a full array of grading and analysis services for both the cornea and retina, including:

  • Corneal endothelial cell density
  • Coefficient of variation
  • Percent of hexagonal cells
  • Epithelial staining analysis
  • Analysis of confocal images of the epithelium and stroma
  • Fundus photography
  • Fluorescein angiography

Contact Us

For more information on the Eye Image Reading Centers or if you have questions, please contact one of the following:

Douglas J. Rhee, M.D., Medical Director, Retinal Image Analysis Reading Center (REDIARC)
Department Chair, Department of Ophthalmology & Visual Sciences
Case Western Reserve University School of Medicine
Phone: 216-844-8590

Jonathan Lass, MD, Medical Director, Cornea Image Analysis Reading Center (CIARC)
Charles I Thomas Professor, Department of Ophthalmology & Visual Sciences
Case Western Reserve University School of Medicine
Phone: 216-844-5893

Beth Ann Benetz, CRA, FOPS Director, Eye Image Reading Centers
Director, Retinal Image Analysis Reading Center (REDIARC)
Director, Cornea Image Analysis Reading Center (CIARC)
Professor, Case Western Reserve University School of Medicine
Phone: 216-844-3615


Please note our new location:

Eye Image Reading Centers
Midtown Tech Park
6700 Euclid Avenue, STE 103
Cleveland, Ohio 44103

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