Completed Trials and Publications

Our latest clinical trials and publications are listed below.


DAWN Study

Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN)

Navigate ESUS Study

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

TeleRehab Study

Telerehabilitation in the Home versus Therapy In-Clinic for Patients with Stroke

SanBio Study

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke (ACTIsSIMA)

This is a controlled study evaluating the stereotactic or minimally invasive injection of SB623 stem cells into the brain of patients with paralysis from a prior ischemic stroke. (Surgical site only – for referrals from recruiting sites).

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This multicenter, randomized trial is studying the efficacy and safety of EG-1962 versus the current standard of care with Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage.

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The purpose of this study is to determine whether treatment with the iron chelator, Deferoxamine Mesylate, improves the outcome of patients who have had an intracerebral hemorrhage.

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This study will evaluate real world usage of the ENROUTE Transcarotid Stent and Transcarotid Neuroprotection System in the management of carotid artery disease.

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This randomized controlled pilot study will examine the efficacy, feasibility and safety of a health promotion and wellness program in stroke survivors.

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This study will test the effectiveness of a novel home-based telehealth system designed to improve motor recovery and patient education after stroke.

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MultiStem Therapy for Stroke

The purpose of this industry-sponsored study is to determine the safety and efficacy of MultiStem (stem cell therapy) in patients with ischemic stroke within 24-36 hours.

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Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)

The purpose of this NIH-funded study is to determine which of two blood pressure targets is superior in reducing hematoma expansion and improving outcomes after acute intracerebral hemorrhage. Stenting & Angioplasty with Protection in Patients at High Risk for Endarterectomy – Sapphire Registry This industry sponsored registry will determine risks of major adverse events in the treatment of carotid occlusive disease with the Cordis PRECISE® Nitinol Stent System and Cordis ANGIOGUARD™ XP/RX Emboli Capture Guidewire.

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Carotid Revascularization with ev3 Arterial Technology Evolution (CREATE)

This industry-sponsored registry will evaluate the efficacy and safety of the ev3's Protege(R) Nitinol Self-Expanding Stent with the company's SPIDER(TM) Embolic Protection Device in the treatment of carotid occlusive disease.

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This study is a multicenter, international, double-blind, randomized study comparing the use of EVD combined with rt-PA against EVD combined with placebo for the treatment of intraventricular hemorrhage.

Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS)

NIH-funded study is to compare the safety and effectiveness of intensive medical therapy plus stenting versus intensive medical therapy only in preventing stroke, heart attacks or death.

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Insulin Resistance Intervention After Stroke Trial (IRIS)

The purpose of this NIH-funded study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.

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Secondary Prevention of Small Subcortical Strokes Trial (SPS3)

The goal of this NIH-funded study is to learn if combination antiplatelet therapy (aspirin and clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and cognitive decline, and if intensive blood pressure control is associated with fewer recurrent strokes and cognitive decline.

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PFO Closure in Cryptogenic Stroke (RESPECT)

The goal of this industry-sponsored study determines if PFO closure with the AMPLATZER PFO Occluder was superior to the current medical standard of care in the prevention or recurrent embolic stroke in patients with a cryptogenic stroke due to presumed paradoxical embolism.

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Targeted Management Intervention for African-American Men with TIA or Stroke (TEAM)

This goal of this NIH-funded study is to determine barriers and facilitators to post-stroke care with the purpose of developing a behavioral intervention to improve adherence with preventive therapies. Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-III) This goal of this NIH-funded study is to determine if intraventricular tPA is superior to the current standard of care in the resolution of intraventricular hemorrhage and improving outcomes after hemorrhagic stroke.

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Minimally Invasive Surgery plus rt=PA for Intracerebral Hemorrhage Evaluation (MISTIE-ICES)

The purpose of this NIH-funded study is to determine if minimally invasive hematoma evacuation is superior to the current medical standard of care in improving outcomes after hemorrhagic stroke. “Non-invasive Brain-Signal Training to Induce Motor Control Recovery After Stroke” Janis J. Daly, PhD, associate professor of neurology at Case Western Reserve University School of Medicine, was awarded a $1 million EUREKA grant from the National Institutes of Health (NIH) to investigate the feasibility of using Electroencephalography (EEG) signals to direct brain retraining following stroke.

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Interventional Management of Stroke (IMS) III Trial (IMS III)

The purpose of this NIH-funded study was to compare two different treatment approaches—combined intravenous and intra-arterial recombinant tissue plasminogen activator (rt-PA) and standard intravenous (IV) rt-PA—to restoring blood flow to the brain.

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Carotid Occlusion Surgery Study (COSS)

The purpose of this NIH-funded study was to determine if extracranial-intracranial bypass surgery, when added to best medical therapy can reduce the subsequent risk of ipsilateral stroke in high-risk patients with recently symptomatic carotid occlusion and increased cerebral oxygen extraction fraction measured by PET.

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Clazosentan in Reducing Vasospasm-Related Morbidity and All-Cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping (CONSCIOUS-2)

The aim of this industry-sponsored study was to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm-related morbidity and all-cause mortality within 6 weeks post-aSAH treated by surgical clipping.

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Clinical Outcome in Acute Stroke Treatment After Image Guided Patient Selection for Interventional Revascularization Therapy (START)

This industry-sponsored study was designed to assess the safety and effectiveness of the Penumbra System in a stroke cohort with a known core infarct volume derived from imaging at admission.

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A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated (FS VH S/D 500 S-apr) Compared to DuraSeal Dural Sealant as an Adjunct to Sutured Dural Repair in Cranial Surgery

EDGE Study

Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage (NEWTON2)

Surgical Theater for Acute Stroke Surgical Therapy

The Surgical Rehearsal Platform allows for pre-operative rehearsal of a planned aneurysm surgery on a computer work station using the patient’s own imaging. The objective of this clinical study is to determine if the use of the Surgery Rehearsal Platform SRP will lead to improved effort and time efficiency in cerebral aneurysm surgery.

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Parkinson’s Disease


A Study to Assess the PK and Pharmacodynamics of IPX203 in Subjects With Advanced Parkinson’s Disease

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