Immunotherapy Research & Clinical Trials

The Angie Fowler Adolescent & Young Adult Cancer Institute at UH Rainbow Babies & Children’s Hospital has a rigorous research program with a national reputation for scientific and translational innovation in pediatric oncology and immunotherapy that extends to include teens and young adults (AYA).

The Adolescent & Young Adult Research Initiative at Case Comprehensive Cancer Center at Case Western Reserve University was established in 2014 through the generous $6.7 million gift from the Fowler family to support AYA cancer research, including gaining a basic understanding of the biology of the metastatic process and of therapy resistance in cancers that occur in this age group, and leveraging expertise in imaging and drug development. In 2017, the initiative has awarded funding to numerous projects that hold great promise for developing new and innovative therapies for cancer patients.

Promising projects underway include:

University Hospitals is one of less than a dozen academic medical centers to have successfully manufactured CAR T-cells for human use on-site in our own laboratory and is the cornerstone of the nation's only National Center for Regenerative Medicine.


Our Research Team

Led by John Letterio, MD, Chief of Pediatric Hematology & Oncology at UH Rainbow and the Jane and Lee Seidman Chair in Pediatric Cancer Innovation, members of the Angie Fowler Adolescent & Young Adult pediatric oncology cancer research team include: