Immunotherapy Research & Clinical Trials
The Angie Fowler Adolescent & Young Adult Cancer Institute at UH Rainbow Babies & Children’s Hospital has a rigorous research program with a national reputation for scientific and translational innovation in pediatric oncology and immunotherapy that extends to include teens and young adults (AYA).
The Adolescent & Young Adult Research Initiative at Case Comprehensive Cancer Center at Case Western Reserve University was established in 2014 through the generous $6.7 million gift from the Fowler family to support AYA cancer research, including gaining a basic understanding of the biology of the metastatic process and of therapy resistance in cancers that occur in this age group, and leveraging expertise in imaging and drug development. In 2017, the initiative has awarded funding to numerous projects that hold great promise for developing new and innovative therapies for cancer patients.
Promising projects underway include:
- Small molecule oral therapy for treatment of resistant tumors
An existing drug approved for adult cancers that neutralizes the immune-suppressive effects of tumors against host immune cells. Early pre-clinical results show effectiveness in advanced sarcoma.
- Cryoablation therapy
Ultra-cold temperatures have been used clinically to destroy bulking tumors, and Dr. Alex Huang’s team has identified a novel biomarker to show why cryoablating certain tumors can elicit an immunotherapy response.
- Naturally derived herbal compounds
Borrowing nature’s own immunotherapeutic agents to activate our body’s immune system; effectiveness potential for sarcoma, melanoma and other hard-to-treat cancers. Dr. Huang and Mei Zhang, PhD, an Assistant Professor of Biomedical Engineering at Case Western Reserve University, have identified a naturally derived compound from oat bran as a potential novel cancer therapeutic. It turns out that the constituent of the oat bran, the outer shell of the oat, is highly immunogenic and can stop tumor growth in mouse models of osteosarcoma, melanoma and pancreatic cancer by eliciting robust anti-tumor immune responses.
- Monoclonal antibodies
From mouse studies, we’ve developed an understanding of the factors that are very critical for tumor systems to survive. These factors serve as new targets for therapy and UH Rainbow investigators have identified new ways to block these factors. It turns out that one of the agents that can do that, natalizumab, is already FDA-approved for treating multiple sclerosis and Crohn’s disease. Natalizumab works to affect white blood cells and reduce inflammation. Early results show it may be effective in treating pediatric sarcoma. UH Rainbow hematologist/oncologist Kristen VanHeyst, DO, is working to open a phase I clinical trial of natalizumab in recurrent, refractory or progressive pulmonary metastatic osteosarcoma at UH Rainbow Babies & Children’s Hospital in the fourth quarter of 2021.Learn more
- Natural killer (NK) cells
A type of white blood cells that can be engineered to destroy tumors. Angie’s Institute would be among the first places in the U.S. to offer this treatment to pediatric patients.
University Hospitals is one of less than a dozen academic medical centers to have successfully manufactured CAR T-cells for human use on-site in our own laboratory and is the cornerstone of the nation's only National Center for Regenerative Medicine.
Our Research Team
Led by John Letterio, MD, Chief of Pediatric Hematology & Oncology at UH Rainbow and the Jane and Lee Seidman Chair in Pediatric Cancer Innovation, members of the Angie Fowler Adolescent & Young Adult pediatric oncology cancer research team include: