Kenneth Remy, MD, MHSc, MSCI, FCCM

Kenneth Remy, MD, MHSc, MSCI, FCCM

Kenneth Remy, MD, MHSc, MSCI, FCCM

Associate Professor and NIH funded physician-scientist, Departments of Internal Medicine, Pediatrics, Pathology, and Biochemistry in the Divisions of Pulmonary Critical Care Medicine and Pediatric Critical Care Medicine

Dr. Remy is a tenure track Associate Professor and NIH funded physician-scientist in the Departments of Internal Medicine, Pediatrics, Pathology, and Biochemistry in the Divisions of Pulmonary Critical Care Medicine and Pediatric Critical Care Medicine. He serves as the Director of the Division of Pulmonary Critical Care Medicine Basic Science and Translational Critical Care Research and Co-Director for Clinical, Basic Science, and Translational Critical Care Research in the Division of Pediatric Critical Care Medicine. Previously, Dr. Remy was an Associate Professor at Washington University in St. Louis in the Departments of Pediatrics and Internal Medicine. At Washington University, Dr. Remy successfully completed the Academic Medical Leadership Program for Physicians and Scientists in the School of Medicine, the Olin Business School and BJC HealthCare.

Dr. Remy is an international expert in adult and pediatric sepsis, COVID disease, and global health. As an adult and pediatric critical care physician, his laboratory is focused on two areas: heme-based trafficking and signaling in immune dysregulation in context of diseases of intravascular hemolysis (COVID, sepsis, malaria, sickle cell disease, thalassemia) and after red blood cell transfusion; and real time immunophenotyping of pro and hypoinflammatory states to identify timing for immunoadjuvant therapies. During the COVID-19 pandemic, Dr. Remy has cared for over two thousand patients in the adult and pediatric ICU while pivoting his laboratory activities to understanding the evolution of the disease in both a hematologic and immune functional approach. Dr. Remy in collaboration with Dr. Richard Hotchkiss were among the first in world to demonstrate a covid-19 immunosuppressive phenotype demonstrating significant T cell exhaustion in patients with critical illness. Dr. Remy’s first authored manuscript on care of adults in the pediatric ICU was the featured article in Pediatric Critical Care Medicine. He has been featured on a number of news programs including CNN, CBS Evening News, BBC News, People Magazine, NBC News, Reuters, USA today, and many other local and international news stations on his experiences during this pandemic and speaking on the immunologic consequences of disease, pediatric multisystem inflammatory syndrome (MIS-C), public health measures and schools, and potential therapies for SARS-CoV-2 infection. Dr. Remy sits on a number of national and international task forces in sepsis and COVID including the NIH, BARDA, FDA, CDC, and many others. Dr. Remy has authored over 75 peer reviewed manuscripts, textbook chapters, and invited commentaries. He is the chair of the basic and translational science research section for the society of critical care medicine (SCCM); the largest society for critical care practitioners in the world with over 25,000 members. Additionally, he is the immunology chair for the pediatric acute lung injury and sepsis investigators blood network, and holds key leadership positions in many other organizations including executive committee of the research section of SCCM and member at large for the Internal Medicine section of SCCM. He has been honored as a fellow in the American College of Critical Care Medicine and fellow in the society of Pediatric Research. Prior to Case Western University, University Hospitals of Cleveland, and Washington University: Dr. Remy holds a Medical Degree from Jefferson Medical College and Masters’ Degrees from Duke University (Clinical Research) and Washington University in St. Louis (Translational Research; immunology focus). He completed dual residencies in Internal Medicine and Pediatrics at Case Western University/University Hospitals of Cleveland/Rainbow Babies and Children’s Hospital in Cleveland, Ohio, Pediatric Critical Care fellowship at New York Presbyterian Hospital-Columbia University in New York City, and Adult Critical Care Fellowship at the National Institutes of Health in Bethesda, MD. He is quadruple boarded in each of these specialties.

Additionally, he is formally trained in Global Health and emergency and disaster preparedness; and has received a certificate of clinical research from the National Institutes of Health. He is also the medical director (ICU captain) for Heart Care International’s Medical Missions and global health chair for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. He Co-founded the first-in-world Global Health Critical Care Fellowship in Blantyre Malawi in 2017 and remains a co-fellowship director.

Dr. Remy’s has clinical interests in both adults and children in bioethics, international health, humor therapy, and palliative care. Previous research has been in calcium activated chloride channels in airway smooth muscle and in therapeutics to bacillus anthracis induced shock. His research interests are in host inflammatory response in sepsis.

Honors and Awards

  • University Hospitals of Cleveland “UH IDOL” Semifinalist, 2006
  • Gary Onady National Internal Medicine-Pediatrics Award Recipient, 2007
  • Who’s Who Among American Doctors, 2007
  • America’s Top Pediatricians, 2007 – 2015
  • Rainbow Ambulatory Practice Senior Resident Award, 2008
  • Co-Chief Fellow (Selected Position), Columbia University School of Physicians and Surgeons/New York Presbyterian Hospital, Pediatric Critical Care Medicine, 2010 – 2011
  • Who’s Who Among American Pediatricians, 2011 – 2015
  • The National Institutes of Health Intramural Loan | Repayment Program Award, 2011 – 2015
  • Chair; Clinical Fellows Committee (Selected Position), The National Institutes of Health, 2012 – 2014
  • Who’s Who Among American Physicians, 2012 – 2015
  • Chair; Fellow Committee (Selected Position), The National Institutes of Health, 2012 – 2014
  • National Food and Drug Regulatory Science Symposium First Place Research Award (Top Award), 2013
  • The National Institutes of Health Clinical Center Director’s Award Recipient, 2013
  • The Accreditation Council for Graduate Medical Education 2014 David C. Leach Award Recipient, 2015
  • American Thoracic Society; Critical Care Section Scientific Abstract Award, 2015
  • The National Institutes of Health Extramural Loan | Repayment Program Award, 2016 – Pres
  • American Thoracic Society Foundation Research Recognition for Early Career Investigators, 2016 – Pres
  • St. Louis Children’s Hospital; Children’s Direct Triple Crown Award, 2017
  • SCCM Weil Research Grant Award, 2018
  • The Society of Pediatric Research (SPR) Membership, 2019 – Pres
  • American College of Critical Care Fellow (FCCM), 2020 – Pres
  • Fellowship in the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine, 2020 – Pres
  • Society for Pediatric Research Member Induction, 2020 – Pres

Education

  • BS, Advanced Honors Certificate, The University of Delaware, 1999
  • BA, Advanced Honors Certificate, The University of Delaware, 1999
  • MD, Jefferson Medical College of Thomas Jefferson University, 2004
  • MSc, Duke University, 2015
  • MSCI, Washington University, 2020
  • Sp, Washington University in St. Louis School of Medicine, Olin Business School, and BJC Healthcare, 2021

Training

  • Internal Medicine and Pediatrics Combined Residency, Case Medical Center; University Hospitals of Cleveland; Rainbow
  • Babies and Childrens Hospital, 2004 – 2008
  • Global Health Track Training Certificate, Case Western University, School of Medicine, 2004 – 2008
  • Management of Humanitarian Emergencies: Focus on Children and Families, Case Western School of Medicine, 2008 – 2008
  • Pediatric Critical Care Medicine Fellowship, Columbia University School of Medicine; New York Presbyterian Hospital, 2008 – 2011
  • Adult Critical Care Medicine Fellowship, The National Institutes of Health, 2011 – 2013
  • Clinical Research Training Certificate With Commendation, The National Institutes of Health, 2012 – 2014
  • Critical Care Medicine Postdoctoral Clinical Research Fellowship , National Institutes of Health, 2013 – 2015

Recent Publications

  1. Mazer MB, Turnbull IR, Miles S, Blood TM, Sadler B, Hess A, Botney MD, Martin RS, Bosanquet JP, Striker DA, Anand NS, Morre M, Caldwell CC, Brakenridge SC, Moldawer LL, Di Paola JA, Hotchkiss RS, Remy KE. Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report. Crit Care Explor. 2021;3(7):e0500. PMCID:PMC8322565 PMID:34345826
  2. Turnbull IR, Mazer MB, Hoofnagle MH, Kirby JP, Leonard JM, Mejia-Chew C, Spec A, Blood J, Miles SM, Ransom EM, Potter RF, Gaut JP, Remy KE, Hotchkiss RS. IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis. Open Forum Infect Dis. 2021;8(6):ofab256. PMCID:PMC8231366 PMID:34189174
  3. Remy KE, Kissoon N. Coronavirus Disease 2019: A Pandemic Spawning an Infodemic. Pediatr Crit Care Med. 2021. PMID:34034307
  4. Mazer MB, Davitt E, Turnbull IR, Caldwell CC, Brakenridge SC, Remy KE, Hotchkiss RS. In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019. Crit Care Explor. 2021;3(4):e0378. PMCID:PMC8021361 PMID:33834168
  5. Justin Robison and Kenneth E Remy . Finding ways for children's doctors to care for big 'Kids' and save adults in a pandemic Arch Dis Child. 2021. doi:doi: 10.1136/archdischild-2021-321628. PMID:33785528
  6. Zee-Cheng J, McCluskey CK, Klein MJ, Scanlon MC, Rotta AT, Shein SL, Pineda JA, Remy KE, Carroll CL. Changes in Pediatric Intensive Care Unit Utilization and Clinical Trends during the Coronavirus Pandemic. Chest. 2021. PMCID:PMC7954775 PMID:33727033
  7. Verhoef PA, Kannan S, Sturgill JL, Tucker EW, Morris PE, Miller AC, Sexton TR, Koyner JL, Hejal R, Brakenridge SC, Moldawer LL, Hotchkiss RS, Blood TM, Mazer MB, Bolesta S, Alexander SA, Armaignac DL, Shein SL, Jones C, Hoemann CD, Doctor A, Friess SH, Parker RI, Rotta AT, Remy KE. Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor. 2021;3(3):e0374. PMCID:PMC7994036 PMID:33786450
  8. Turnbull I, Fuchs A, Remy K, Kelly M, Frazier E, Ghosh S, Chang SW, Mazer M, Hess A, Leonard J, Hoofnagle M, Colonna M, Hotchkiss R. Dysregulation of the Leukocyte Signaling Landscape during Acute COVID-19. Res Sq. 2021. PMCID:PMC7899466 PMID:33619472
  9. Muttalib F, Ballard E, Langton J, Malone S, Fonseca Y, Hansmann A, Remy K, Hovmand P, Doctor A. Application of systems dynamics and group model building to identify barriers and facilitators to acute care delivery in a resource limited setting. BMC Health Serv Res. 2021;21(1):26. PMID:33407458
  10. Mazer MB, Caldwell C, Hanson J, Mannion D, Turnbull IR, Drewry A, Osborne D, Walton A, Blood T, Moldawer LL, Brakenridge S, Remy KE, Hotchkiss RS. A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients. J Immunol. 2020. PMID:33239423
  11. Mudd PA, Crawford JC, Turner JS, Souquette A, Reynolds D, Bender D, Bosanquet JP, Anand NJ, Striker DA, Martin RS, Boon ACM, House SL, Remy KE, Hotchkiss RS, Presti RM, O'Halloran JA, Powderly WG, Thomas PG, Ellebedy AH. Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm. Sci Adv. 2020. PMID:33187979
  12. Mudd PA, Remy KE. Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity? J Clin Invest. 2020. PMID:33104057
  13. Phares TW, Kotraiah V, Chung CS, Unsinger J, Mazer M, Remy KE, Browne CD, Buontempo P, Mansour M, Pannucci J, Ayala A, Hotchkiss RS, Gutierrez GM. A Peptide-Based Checkpoint Immunomodulator Alleviates Immune Dysfunction in Murine Polymicrobial Sepsis. Shock. 2020. PMID:33065715
  14. Orr WB, Elward AM, Lin JC, Reich PJ, Scheel JN, Hayes EV, Remy KE. Delayed Development of Coronary Artery Dilation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed. Crit Care Explor. 2020;2(10):e0236. PMCID:PMC7531755 PMID:33063036
  15. Kaselitz, Timothy B. MD, MPH; Dezfulian, Cameron MD; Remy, Kenneth E. MD, MHSc. The authors reply: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists Pediatr Crit Care Med. 2020. PMCID:PMC7437422 PMID:32769699
  16. Remy KE, Mazer M, Striker DA, Ellebedy AH, Walton AH, Unsinger J, Blood TM, Mudd PA, Yi DJ, Mannion DA, Osborne DF, Martin RS, Anand NJ, Bosanquet JP, Blood J, Drewry AM, Caldwell CC, Turnbull IR, Brakenridge SC, Moldawer LL, Hotchkiss RS. Severe immunosuppression and not a cytokine storm characterize COVID-19 infections. JCI Insight. 2020. PMID:32687484
  17. Laterre PF, François B, Collienne C, Hantson P, Jeannet R, Remy KE, Hotchkiss RS. Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19). JAMA Netw Open. 2020;3(7):e2016485. PMID:32697322
  18. Mudd PA, Crawford JC, Turner JS, Souquette A, Reynolds D, Bender D, Bosanquet JP, Anand NJ, Striker DA, Martin RS, Boon ACM, House SL, Remy KE, Hotchkiss RS, Presti RM, OHalloran JA, Powderly WG, Thomas PG, Ellebedy AH. Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease. medRxiv. 2020. PMCID:PMC7274224 PMID:32511543
  19. Remy KE, Verhoef PA, Malone JR, Ruppe MD, Kaselitz TB, Lodeserto F, Hirshberg EL, Slonim A, Dezfulian C. Feature Article: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists. Pediatr Crit Care Med. 2020. PMID:32420720
  20. Remy KE, Brakenridge SC, Francois B, Daix T, Deutschman CS, Monneret G, Jeannet R, Laterre PF, Hotchkiss RS, Moldawer LL. Immunotherapies for COVID-19: lessons learned from sepsis. Lancet Respir. Med. 2020. PMID:32444269
  21. Remy KE, Lin JC, Verhoef PA. High-flow nasal cannula may be no safer than non-invasive positive pressure ventilation for COVID-19 patients. Crit Care. 2020;24(1):169. PMID:32326959
  22. Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the PlasmaTV Investigators and the P3T Investigators. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatr Crit Care Med. 2020;21(3):267-275. PMCID:PMC7060816 PMID:31644453
  23. Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019;322(22):2179-2190. PMID:31821429
  24. Remy KE, Cortés-Puch I, Sun J, Feng J, Lertora JJ, Risoleo T, Katz J, Basu S, Liu X, Perlegas A, Kim-Shapiro DB, Klein HG, Natanson C, Solomon SB. Haptoglobin therapy has differential effects depending on severity of canine septic shock and cell-free hemoglobin level. Transfusion. 2019. PMID:31639229
  25. Mazer M, Unsinger J, Drewry A, Walton A, Osborne D, Blood T, Hotchkiss R, Remy KE. IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients. J Immunol. 2019. PMID:31501258
  26. Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators., P3T Investigators. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children. Pediatr Crit Care Med. 2019;20(2):e61-e69. PMID:30422914
  27. Remy KE, Cortés-Puch I, Solomon SB, Sun J, Pockros BM, Feng J, Lertora JJ, Hantgan RR, Liu X, Perlegas A, Warren HS, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Haptoglobin improves shock, lung injury, and survival in canine pneumonia. JCI Insight. 2018;3(18). PMID:30232287
  28. Kanak Rajah, E.; Ballard, E.; Remy, K.; Hovmand, P.; Taylor, T.; Postels, D.; Green, J.; Muttalib, F.; Fonseca, Y.; Doctor, . Abstract P-132: PEDIATRIC CRITICAL CARE IMPLEMENTATION IN RESOURCE LIMITED SETTINGS APPLICATION OF COMMUNITY-BASED GROUP MODEL BUILDING PCCM. 2018;Volume 19 - Supplement 1 (6S). doi:doi: 10.1097/01.pcc.0000537589.72326.4d
  29. Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S121-S126. PMID:30161066
  30. Steiner ME, Zantek ND, Stanworth SJ, Parker RI, Valentine SL, Lehmann LE, Josephson CD, Bateman ST, Luban NLC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S149-S156. PMID:30161070
  31. Doctor A, Cholette JM, Remy KE, Argent A, Carson JL, Valentine SL, Bateman ST, Lacroix J, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S98-S113. PMID:30161064
  32. Steffen KM, Bateman ST, Valentine SL, Small S, Spinella PC, Doctor A, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Implementation of the Recommendations for RBC Transfusions for Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S170-S176. PMID:30161073
  33. Tasker RC, Turgeon AF, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusion in Critically Ill Children With Acute Brain Injury From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S133-S136. PMID:30161068
  34. Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S127-S132. PMID:30161067
  35. Zantek ND, Parker RI, van de Watering LM, Josephson CD, Bateman ST, Valentine SL, Delaney M, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S163-S169. PMID:30161072
  36. Cholette JM, Willems A, Valentine SL, Bateman ST, Schwartz SM, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S137-S148. PMID:30161069
  37. Demaret P, Emeriaud G, Hassan NE, Kneyber MCJ, Valentine SL, Bateman ST, Tucci M, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S114-S120. PMID:30161065
  38. Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9):884-898. PMID:30180125
  39. Bembea MM, Cheifetz IM, Fortenberry JD, Bunchman TE, Valentine SL, Bateman ST, Steiner ME, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S157-S162. PMID:30161071
  40. Bembea MM, Valentine SL, Bateman ST, Wilson LM, Anton B, Harger N, Robinson KA, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S93-S97. PMID:30161063
  41. Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators. Platelet Transfusion Practices in Critically Ill Children. Crit Care Med. 2018;46(8):1309-1317. PMID:29727368
  42. Remy, K.; Holloway, A.; Taylor, T.; Postels, D.; Fonseca, Y.; Muttalib, F.; Bhutta, A; Doctor, A. Abstract P-144: TRAINING OF PEDIATRIC INTENSIVISTS FOR CLINICAL SERVICE AND SCHOLARSHIP IN RESOURCE-LIMITED SETTINGS PCCM. 2018;19:92(6S). doi:DOI: 10.1097/01.pcc.0000537601.84894.e3
  43. Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PLoS One. 2018;13(6):e0199497. PMCID:PMC6019671 PMID:29944697
  44. Remy KE, Yazer MH, Saini A, Mehanovic-Varmaz A, Rogers SR, Cap CAP, Spinella PC. Effects of Platelet Sparing Leukocyte Reduction and Agitation Methods on In Vitro Measures of Hemostatic Function in Cold-Stored Whole Blood. J Trauma Acute Care Surg. 2018. PMID:29554042
  45. Gokanapudy LR, Remy KE, Karuppiah S, Melgar Humala EV, Abdullah I, Ruppe MD, Schechter WS, Michler R, Tobias JD. Successful Surgical Repair and Perioperative Management of 6-Month-Old With Total Anomalous Pulmonary Venous Return in a Developing Country: Considerations for the Treatment of Pulmonary Hypertension. Cardiol Res. 2018;9(1):53-58. PMCID:PMC5819631 PMID:29479388
  46. Kenneth E. Remy MD, MHSc , Mark W. Hall MD, Jill Cholette MD, Nicole P. Juffermans MD, Kathleen Nicol MD, Allan Doctor MD, Neil Blumberg MD, Philip C. Spinella MD , Philip J. Norris MD, Mary K. Dahmer PhD, and Jennifer A. Muszynski MD, MPH. Mechanisms of Red Blood Cell Transfusion-Related Immunomodulation (TRIM) Transfusion. 2018. PMID:29383722
  47. Remy KE, Custer JW, Cappell J, Foster CB, Garber NA, Walker LK, Simon L, Bagdure D. Pediatric Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Review with Pooled Analysis and Critical Care Emphasis. Front Pediatr.. 2017;5:250. PMCID:PMC5705558 PMID:29226117
  48. Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ. Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. Intensive Care Med Exp. 2017;5(1):48. PMID:29058092
  49. Coletti KD, Bagdure DN, Walker LK, Remy KE, Custer JW. High-Flow Nasal Cannula Utilization in Pediatric Critical Care. Respir Care. 2017;62(8):1023-1029. PMID:28588119
  50. Muszynski JA, Spinella PC, Cholette JM, Acker JP, Hall MW, Juffermans NP, Kelly DP, Blumberg N, Nicol K, Liedel J, Doctor A, Remy KE, Tucci M, Lacroix J, Norris PJ, Pediatric Critical Care Blood Research Network (Blood Net). Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness. Transfusion. 2017;57(1):195-206. PMID:27696473
  51. Kienzle M, Attebery J, Custer J, Remy K. High-Flow Nasal Oxygen Reduces Intubation in Critically Ill Children With Respiratory Failure. Critical Care Medicine. 2016;44. doi:10.1097/01.ccm.0000509697.97426.5b PMID:27850659
  52. Remy AM, Remy KE, Rosenbaum JL. Palliative Care-Led Meetings for Families of ICU Patients. JAMA. 2016;316(15):1597-1598. PMID:27755629
  53. Remy KE, Spinella PC. Red blood cell storage age – what we know from clinical trials. Expert Rev Hematol. 2016. PMID:27686118
  54. Attebery JE, Lin JC, Remy KE. High-Flow Oxygen as Noninvasive Ventilation May Complicate Timely Intubation in Patients With Acute Respiratory Distress Syndrome. Crit Care Med. 2016;44(8):e768-9. PMID:27428147
  55. Kenneth E. Remy, Irene Cortes-Puch, Charles Natanson and Harvey G. Klein. Transfused fresh blood does not improve outcome, but safety of the oldest stored units still needs to be established compared to current practice Blood. 2016;127(4).
  56. Remy KE, Sun J, Wang D, Welsh J, Solomon SB, Klein HG, Natanson C, Cortés-Puch I. Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis. Vox Sang. 2016. doi:10.1111/vox.12380 PMID:26848822
  57. Suffredini DA, Sampath-Kumar H, Li Y, Ohanjanian L, Remy KE, Cui X, Eichacker PQ. Does Bacillus anthracis Lethal Toxin Directly Depress Myocardial Function? A Review of Clinical Cases and Preclinical Studies. Toxins (Basel). 2015;7(12):5417-34. PMCID:PMC4690141 PMID:26703730
  58. Cortés-Puch I, Remy KE, Solomon SB, Sun J, Wang D, Al-Hamad M, Kelly SM, Sinchar D, Bellavia L, Kanias T, Popovsky MA, Kim-Shapiro DB, Klein HG, Natanson C. In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome. Transfusion. 2015;55(11):2564-75. PMCID:PMC4644122 PMID:26469998
  59. Irene Cortés-Puch, Kenneth E. Remy, Steven B. Solomon, Junfeng Sun, Dong Wang, Mariam Al-Hamad, Seth M. Kelly, Derek Sinchar, Landon Bellavia, Tamir Kanias, Mark A. Popovsky, Daniel B. Kim-Shapiro, Harvey G. Klein and Charles Natanson. In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome Transfusion. 2015;00(0):0.
  60. Shein SL, Remy KE. High-Flow Nasal Cannula Oxygen in Respiratory Failure. N Engl J Med. 2015;373(14):1373-1375. doi:10.1056/NEJMc1508390#SA3 PMID:26422732
  61. Solomon SB, Cortés-Puch I, Sun J, Remy KE, Wang D, Feng J, Khan SS, Sinchar D, Kim-Shapiro DB, Klein HG, Natanson C. Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model. Transfusion. 2015. doi:10.1111/trf.1321326175134
  62. Remy KE. Sedation protocol for critically ill pediatric patients. JAMA. 2015;313(17):1754. doi:10.1001/jama.2015.3459 PMID:25942730
  63. Ohanjanian L, Remy KE, Li Y, Cui X, Eichacker PQ. An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis. Expert Opin Investig Drugs. 2015;1-15. doi:10.1517/13543784.2015.1041587 PMID:25920540
  64. Remy KE, Natanson C, Klein HG. The influence of the storage lesion(s) on pediatric red cell Transfusion. Curr Opin Pediatr. 2015. doi:10.1097/MOP.0000000000000224 PMID:25888156
  65. Kadri SS, Remy KE, Strich JR, Gea-Banacloche J, Leitman SF. Role of granulocyte transfusions in invasive fusariosis: systematic review and single-center experience. Transfusion. 2015. doi:10.1111/trf.13099 PMID:25857209
  66. Remy KE, Chertow DS. A place at the table for children in the ebola virus disease discussion. Pediatr Crit Care Med. 2015;16(2):184-5. doi:10.1097/PCC.0000000000000368 PMID:25647125
  67. Remy KE, Cui X, Li Y, Sun J, Solomon SB, Fitz Y, Barochia AV, Al-Hamad M, Moayeri M, Leppla SH, Eichacker PQ. Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines. Intensive Care Med Exp. 2015;3(9). doi:10.1186/s40635-015-0043-4 PMID:26097803
  68. Wang D, Cortés-Puch I, Sun J, Solomon SB, Kanias T, Remy KE, Feng J, Alimchandani M, Quezado M, Helms C, Perlegas A, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014;54(7):1712-24. doi:10.1111/trf.12607 PMCID:PMC4214924 PMID:24588210
  69. Cortés-Puch I, Wang D, Sun J, Solomon SB, Remy KE, Fernandez M, Feng J, Kanias T, Bellavia L, Sinchar D, Perlegas A, Solomon MA, Kelley WE, Popovsky MA, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood. 2014;123(9):1403-11. doi:10.1182/blood-2013-11-539353 PMCID:PMC3938151 PMID:24366359
  70. Gallos G, Remy KE, Danielsson J, Funayama H, Fu XW, Chang HY, Yim P, Xu D, Emala CW Sr. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2013;305(9):L625-34. doi:10.1152/ajplung.00068.2013 PMCID:PMC3840275 PMID:23997176
  71. Remy KE, Qiu P, Li Y, Cui X, Eichacker PQ. B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components. BMC Med. 2013;11:217. doi:10.1186/1741-7015-11-217 PMCID:PMC3851549 PMID:24107194
  72. Li Y, Cui X, Solomon SB, Remy K, Fitz Y, Eichacker PQ. B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model. Am J Physiol Heart Circ Physiol. 2013;305(2):H238-50. doi:10.1152/ajpheart.00185.2013 PMCID:PMC3726957 PMID:23585140
  73. Remy KE, Elder RW, Tsankova NM, Conroy RM. Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease. J Pediatr Endocrinol Metab. 2012;25(11-12):1195-9. doi:10.1515/jpem-2012-0162 PMID:23329771