2016 Harrington Prize Recipient
Dr. Jeffrey Friedman is a physician-scientist studying the genetic mechanisms that regulate body weight. Dr. Friedman's research on various aspects of obesity received national attention in late 1994, when it was announced that he and his colleagues had isolated the mouse ob gene and its human homologue. They subsequently found that injections of the encoded protein, leptin, decrease body weight of mice by reducing food intake and increasing energy expenditure. Current research is aimed at understanding the genetic basis of obesity in human and the mechanisms by which leptin transmits its weight-reducing signal.
He is currently a Professor at the Rockefeller University, an Investigator at the Howard Hughes Medical Institute and the Director of the Starr Center for Human Genetics. Dr. Friedman's affiliation with The Rockefeller University began in 1980, where he was awarded a Ph.D. degree in 1986. He was appointed Assistant Investigator with the Howard Hughes Medical Institute at Rockefeller in 1986, promoted to Associate Investigator in 1991, and Investigator in 1997. Dr. Friedman received an M.D. degree from Albany Medical College in 1977 and completed a medical residency at Albany Medical College in 1980.
Dr. Friedman was born in Orlando, Florida, on July 20, 1954, and grew up in North Woodmere, Long Island. He graduated from Renssalaer Polytechnic Institute magna cum laude and, at the age of 22, received his medical degree from Albany Medical College of Union University in Albany, New York. While at Albany Medical College, he was elected to Alpha Omega Alpha, the medical honor society. After completing a residency in Internal Medicine at Albany Medical Center Hospital, Dr. Friedman came to Rockefeller as a postgraduate fellow and associate physician in 1980. From 1980 to 1981, he also served as a postgraduate fellow at Cornell University Medical College. In 1986, he received a Ph.D. under the tutelage of Professor James E. Darnell, was appointed assistant professor, and became an assistant investigator at the Howard Hughes Medical Institute. Dr. Friedman was appointed Professor at Rockefeller in 1995 after serving as Associate Professor and Head of Laboratory of Molecular Genetics at the Institution since 1991 and in 1998 awarded the Marilyn M. Simpson Professorship. In 1995 he was appointed Director of the Starr Foundation Center for Human Genetics.
Dr. Friedman was elected to the National Academy of Science in 2001. His work was referred to in Time Magazine’s Best of Science Section in 1995 and 1996. He has also received Popular Science’s Best of Science Award in 1995, the Alumnus of the Year Award, 1996, from Albany Medical College, the Heinrich Wieland Prize, 1996, the Jacobaeus Prize, University of Goteborg, 1997, the Steven C. Beering Award, Indiana University School of Medicine, 1999, the Janssen Award for Special Achievement in Gastroenterology, 1999, the Endocrinology Transatlantic Medal, Society for Endocrinology, United Kingdom, 2000, the Osborne Mendel Award, American Society for Nutritional Sciences, 2000, the Rolf Luft Award, Karolinska Hospital, Stockholm, Sweden, 2000, and the Bristol-Myers Squibb Award for Distinguished Achievement in Metabolic Research. He has delivered the Shelton Lecture, Harvard University, 1996, the Peters' Lecture, Yale University, 1996, the Carl Vernon Moore Lecture, Washington University, 1997, the Allan D. Bass Lecture, Vanderbilt University, 1997, the Priscilla White Lecture, Joslin Diabetes Center, 1998, the Chilton Foundation Lecture, University of Texas, 1998, the Jack Gross Memorial Lecture, Israel, 1998, the Van Wyck Lecture, University of North Carolina, 1999, the Verna and Marrs McLean Lecture, Baylor College of Medicine, 1999, the Banting Lecture of the British Diabetes Association, 2002 the Passano Award, 2005, elected to The Royal Swedish Academy of Sciences, Foreign Member, 2005, the Gairdner International 2005, Kovalenko Medal, 2006, Honorary Doctorate, Molecular Genetics, Maastricht University, The Netherlands, 2006, Danone International Prize for Nutrition, 2007, Keio Medical Science Prize, Keio University, 2009, Shaw Prize for Life Sciences and Medicine, 2009, Thomson Reuters Citation Laureate, 2010, Pasarow Foundation Award, 2010, the Albert Lasker Basic Medical Research Award, 2010, The Foundation IPSEN 11th Endocrine Regulation Prize, 2012, BBVA Frontier of Knowledge Award, 2013, and The King Faisal International Prize in Medicine, 2013, elected to American Academy of Arts and Sciences, 2013, and honorary doctorate, Yale University, 2015.