Seth Field, MD, PhD
Investigator, Harrington Discovery Institute, University Hospital Health System
Becky Hennessy Endowed Master Clinician in Breast Cancer Genomics
Professor of Medicine, Division of Endocrinology, Case Western Reserve University
Our goal is to use discoveries in fundamental biology to fuel the development of new approaches to treat human disease.
The Field lab discovered molecular machinery that drives vesicle budding at the Golgi, acting as a fundamental component of the cellular secretory pathway. We established that this machinery serves as a hub for intracellular signaling pathways that regulate Golgi function. Furthermore, abnormal activation of this Golgi secretory machinery serves as a driver of many human cancers.
Our lab is providing new insight into this mysterious organelle, the Golgi, its regulation, and its contribution to human pathophysiology using diverse, state of the art approaches in cell and molecular biology, genetics, biochemistry, and pharmacology.