Atul Chopra, MD, PhD oversees Clemens Duerrschmid, PhD and Wei Xie, PhD in the lab


Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.

Mishra I, Duerrschmid C, Ku Z, He Y, Xie W, Silva ES, Hoffman J, Xin W, Zhang N, Xu Y, An Z, Chopra AR.
Elife. 2021 Apr 27;10:e63784. doi: 10.7554/eLife.63784.
PMID: 33904407

Energy Regulation Mechanism and Therapeutic Potential of Asprosin.

Hoffmann JG, Xie W, Chopra AR.
Diabetes. 2020 Apr;69(4):559-566. doi: 10.2337/dbi19-0009.
PMID: 32198197

Asprosin is a centrally acting orexigenic hormone.

Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR.
Nat Med. 2017 Nov 6. doi: 10.1038/nm.4432. Epub ahead of print 2017 Nov 6.
PMID: 29106398

Asprosin, a Fasting-Induced Glucogenic Protein Hormone.

Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR.
Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.
PMID: 27087445

Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke’s Disease.

Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW.
Science. 2008 November 28;322(5906):1395-9.
PMID: 19039140

Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator Mediated Dietary Fuel Absorption.

Chopra AR, Kommagani R, Saha P, Song J, Jeong JW, Louet JF, Salazar C, Finegold M, Viollet B, Demayo F, Chan L, Moore D, O'Malley BW.
Cell Metabolism. 2011 January 5;13(1):35-43.
PMID: 21195347

The Coactivator SRC-1 is an Essential Coordinator of Hepatic Glucose Production.

Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, Demayo F, Xu J, Newgard CB, O'Malley BW.
Cell Metabolism. 2010 December 1;12(6):606-18.
PMID: 21109193

Foxa2-Dependent Hepatic Gene Regulatory Networks Depend on Physiological State.

Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH.
Physiol Genomics. 2009 July 9;38(2):186-95.
PMID: 19417011

Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy.

York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW.
Cell Metabolism. 2012 May 2;15(5):752-63.
PMID: 22560224

Editorials Featuring our Work

Metabolic disease: Novel fat-secreted hormone regulates glucose homeostasis.

Gene Hunting Reveals New Hormone.
Garber KB. This Month in Genetics. American Journal of Human Genetics 2016 May 5, 98(5):799-800. doi:10.1016/j.ajhg.2016.04.005

Liver: Asprosin – new hormone involved in hepatic glucose release.

Asprosin – new hormone involved in hepatic glucose release.
Greenhill C. Nat Rev Endocrinol. 2016 Jun;12(6):312. doi: 10.1038/nrendo.2016.66. Epub 2016 Apr 29.
PMID: 27125501

Metabolic disease: Novel fat-secreted hormone regulates glucose homeostasis.

Crunkhorn S. Nat Rev Drug Discov. 2016 Jun;15(6):382-3. doi: 10.1038/nrd.2016.98. Epub 2016 May 13.
PMID: 27173941

A Spotlight on Appetite.

Beutler LR, Knight ZA. A Spotlight on Appetite. Neuron. 2018 Feb 21;97(4):739-741.
PMID: 29470967

The Harrington Project for Discovery & Development

Breakthrough Medicine