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Eligibility Criteria

To be eligible for the award, an applicant must meet the following requirements:

  • Hold an MD or MD/PhD (or equivalent)
  • Hold a faculty position at an accredited academic medical center, university or research institution in the US, and conduct the majority of his/her research activities at that institution
  • A project may have only a single PI, who is responsible for project oversight and financial management. The PI may engage collaborators, core labs or commercial CROs to execute any fraction of the project.
  • Past recipients of Harrington Scholar-Innovator awards may submit new and distinct proposals, but may not seek additional support for previously funded projects.

Late submissions will not be accepted for any reason, other than issues with the Harrington Discovery Institute’s submission system. Proposals received by HDI after the deadline will not be reviewed.

Sponsoring Institution Requirements

Investigators may apply from accredited academic medical centers, research institutions or universities in the U.S., and U.S. territories. Institutions must provide the necessary facilities and infrastructure for the research, and accept the conditions of the award, including the Budget & Use of Funds. They must assure compliance with the prevailing national guidelines for animal and human studies, and provide proper oversight of the Grant funds.

Sponsoring institutions must safeguard the rights and welfare of individuals who participate as subjects in research activities by reviewing proposed activities through an Institutional Review Board (IRB) as specified by the U.S. Department of Health and Human Services Office for Human Research Protections, HHS OHRP. Additionally, the Grantee’s institution must assure appropriate governance of animal studies. IRB approval and IACUC numbers are not required at the time of application, but must be provided for final signature of the Grant Agreement, which will be sent to Grantees shortly after they have been selected.

Additionally, sponsoring institutions must adhere to current US Department of Health and Human Services guidelines regarding financial conflict of interest, recombinant DNA and research misconduct.


As a part of The Harrington Project, members of Harrington Discovery Institute, Takeda and Rare Disease Scientific Advisory Council involved in reviewing applications for the Harrington Rare Disease Scholar Award are required to complete mutual Confidentiality & Disclosure Agreements with the Harrington Discovery Institute.

Non-public applicant information is always kept confidential (and limited in distribution to the reviewers and Harrington Discovery Institute administrative team). The abstract summary, including the applicant’s name and institutional affiliation, for those selected as Harrington Rare Disease Scholars may be used by Harrington Discovery Institute for publicity and marketing purposes (on the Harrington Discovery Institute website, new releases, etc.) at Harrington Discovery Institute’s sole discretion.

Applicants acknowledge that University Hospitals Health System may conduct research that is related to, or competitive with, proposals submitted by applicants, but University Hospitals Health System commits not to use information submitted by applications in connection with research.

Harrington Scholar Review Panel

The review panel will consist of subject matter experts with specialized scientific expertise in the area(s) designated in the application, as well as seasoned professionals with expertise in drug development and commercialization.

Projects will be assessed based on:

  • Quality of the science and the scientist
  • Novelty and innovative quality of the work
  • Potential for impact on human health

Applicants who fail to fill out their applications by the deadline and/or in accordance with the detailed instructions are subject to disqualification at the outset of the review period or any time during the review period.

Comments from Review Committee

Harrington Discovery Institute is unable to provide reviewers’ comments or feedback.

Annual Scientific Symposium

Part of Harrington Discovery Institute’s mission is to build a broad connected community of physician-scientist-innovators. Harrington Discovery Institute will hold an annual symposium that awardees are required to attend.

The Harrington Scientific Symposium, held in late spring in Cleveland, Ohio, will bring together drug development experts, national disease foundation leadership, and international leaders in medicine and Harrington Scholars. Awardees are expected to present their project and findings-to-date. A stipend for travel and lodging will be provided by Harrington Discovery Institute, subject to the terms of the Award Agreement.

Use of Funds

  • General: No more than $10,000 of the total grant can be used for capital expenditures or equipment. The award may only be used for direct project expenses, not for institutional overhead.
  • Salary: The award may be used to cover salaries for post-docs equivalent to the percentage of effort devoted to the project. Please note that PI’s salary is limited to 10% of the total award amount.
  • Travel: The award may not be used for travel, meetings, professional fees, publication fees, etc.

Intellectual Property Guidelines

Harrington Discovery Institute does not claim any rights whatsoever to patents, copyrights or trademarks to intellectual property (IP) created as a result of work sponsored by a Harrington grant.

  • On all aspects of Intellectual Property, Principal Investigators are encouraged to confer with their technology transfer office and/or office of sponsored programs for guidance. Harrington Rare Disease Scholars may seek input and advice on patent protection from Harrington Discovery Institute’s Innovation Support Center, which also claims no rights whatsoever to IP.
  • Awardees should take measures to ensure protection of any Intellectual Property in accord with Federal and institutional requirements.

Scientific Reporting & Review of Progress

Yearly renewal of the award is dependent on timely submission of a written progress report, as well as attendance at Harrington Discovery Institute’s Scientific Symposium.

Changes to Project

A significant change in the project scope or work should be discussed with Harrington Discovery Institute’s Program Director and Chief Scientific Officer.

Awards may be transferred to another institution that agrees to assume the Policies, Terms & Conditions of the agreement. Permission to transfer the award to another institution must be obtained from Harrington Discovery Institute’s Chief Scientific Officer.

Compliance & Administrative Matters

Awards are managed by Harrington Discovery Institute. Harrington Discovery Institute staff will assure compliance with program policies and will be responsible for all administrative matters.

The Principal Investigator and his/her institution are solely responsible for execution of the project, including compliance with all relevant Federal and State laws and guidelines.

Harrington Discovery Institute reserves the right to refine and amend policies as required.


Any questions should be directed to HDIQuestions@HarringtonDiscovery.org.

The Harrington Project for Discovery & Development

Breakthrough Medicine