Eye Image Analysis Reading Centers
The Eye Image Analysis Reading Centers’ mission is to provide superior image analysis and trial development support for clinical trials and studies examining the effects of drugs, devices and diseases on the cornea and the retina.
The Eye Image Analysis Reading Centers at University Hospitals Eye Institute and Case Western Reserve University comprises two of the leading ophthalmic image analysis centers:
Established at University Hospitals Cleveland Medical Center and Case Western Reserve University, the two eye image analysis reading centers have extensive experience with multicenter, national and international, federal and corporate-sponsored clinical trials. Our standardized protocols ensure rapid and consistent analyses, while our technical expertise results in refined acquisition, training and analysis techniques. This technical expertise is enhanced by significant medical director involvement in study design to ensure the highest quality and limit inconsistencies.
The Eye Image Analysis Reading Centers are governed by the University Hospitals Institutional Review Board, which is fully accredited by the Association for the Accreditation of Human Research Protection Programs. Our staff follows the regulations set forth by Good Clinical Practices, International Conference on Harmonization, Department of Health and Human Services, and Food and Drug Administration regulations.
Our work with nationally recognized principal investigators, contract research organizations, federal agencies and large pharmaceuticals allows us to tailor our analyses toward improved anatomic and body composition data while maintaining scientific integrity.
We provide image analysis for a variety of ophthalmic diseases, including:
- Diabetic macular edema
- Fuchs' dystrophy
- Neovascular and non-neovascular macular degeneration
- Neuro-ophthalmological diseases
- Vitreoretinal interface disorders
We also evaluate corneal endothelial safety and toxicity related to devices in the anterior chamber, corneal and intraocular surgery and viscoelastics; and retinal safety related to intravitreal medications. Additionally, the center grades ocular images for safety studies of drugs used in non-ophthalmological studies.
We offer a full array of grading and analysis services for both the cornea and retina, including:
- Corneal endothelial cell density
- Coefficient of variation
- Percent of hexagonal cells
- Epithelial staining analysis
- Analysis of confocal images of the epithelium and stroma
- Analysis of optical coherence tomography images of the cornea and anterior chamber
- Fundus photography
- Fluorescein angiography
For more information on the Eye Image Analysis Reading Centers or if you have questions, please contact one of the following:
Douglas J. Rhee, M.D.
Department Chair, Department of Ophthalmology & Visual Sciences
Case Western Reserve University School of Medicine and University Hospitals Eye Institute
Jonathan Lass, MD
Director, University Hospitals Eye Image Analysis Reading Centers
Medical Director, Cornea Image Analysis Reading Center (CIARC)
Charles I Thomas Professor, Department of Ophthalmology & Visual Sciences
Case Western Reserve University School of Medicine
Beth Ann Benetz, CRA, FOPS
Scientific Director, Eye Image Reading Centers
Director, Retinal Image Analysis Reading Center (REDIARC)
Director, Cornea Image Analysis Reading Center (CIARC)
Professor, Case Western Reserve University School of Medicine
Eye Image Analysis Reading Centers
Midtown Tech Park
6700 Euclid Avenue, Suite 103
Cleveland, Ohio 44103