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Shakeel Shareef, MD

Shakeel Shareef, MD



128 Ratings 31 Reviews

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Dr. Shakeel Shareef, MD, joined the University Hospitals Eye Institute July 1, 2019 and serves as the director of the Glaucoma Service and oversees the Glaucoma Fellowship Program. He performs a variety of complex anterior segment surgeries including traditional and micro-invasive glaucoma surgeries, complex cataract procedures, traumatic iris and cyclodialysis cleft repair.

Dr. Shareef was born in Bangalore, India and settled in Flushing Queens, N.Y., at the young age of 5. After completing his primary and secondary education, he graduated from Queens College of the City University of New York with a focus in Chemistry and was a recipient of the Merck Index Award. He completed his medical school and residency at the New York Medical College training in several hospitals in Manhattan, Bronx and Westchester County. While a medical student, he engaged in glaucoma research and worked on establishing a rat glaucoma model with neuroscientist Professor Sansar Sharma, PhD, in the Department of Cell Biology and Anatomy. This model was the first to demonstrate that the death of retinal ganglion cells (RGC) in glaucoma was not a passive but an active process known as apoptosis.

His work led to him pursuing a glaucoma research fellowship at Washington University Department of Ophthalmology and Visual Sciences in St. Louis, Mo. Dr. Shareef worked on characterizing a family of enzymes known as nitric oxide synthase (NOS) in the rat glaucoma model. His work led to the identification of one isoform, NOS 2 found in close proximity to the RGC axons only within the optic nerve of glaucomatous eyes compared to normal controls. It was postulated that NOS 2 plays a toxic role in the death of these ganglion cells by producing a signaling molecule nitric oxide. This opened the door to explore pharmacologic intervention to counter the toxic effects of NOS 2 in halting glaucoma progression. His work was selected for a travel fellowship grant from the Retina Research Foundation.

Dr. Shareef completed an additional year as a glaucoma fellow at Barnes Hospital at the same institution. He subsequently joined the Department of Ophthalmology at Geisinger Medical Center in Danville, Pa., in 1998 caring for patients and teaching eye residents. He continued his clinical research and conducted a survey and chart review of 120 consecutive glaucoma patients to determine the prevalence of avoidance of over the counter (OTC) medications with warning labels for narrow angle glaucoma. The majority (83 percent) had open angles and of those avoiding OTC drugs, 82 percent did so unnecessarily, emphasizing the need to better educate such patients due to their fear of going blind if they did consume such drugs. This work was presented at the annual meeting of the American Academy of Ophthalmology (AAO) and was featured in their magazine.

Dr. Shareef also collaborated with his medical school mentor in isolating and harvesting 13-day fetal rat embryonic spinal cord stem cells (SCSC). Following mechanical injury to the adult rat retina, subsequent injection of fluorescent-labeled SCSC into the vitreous demonstrated at 5 weeks post-injection their capacity to migrate and differentiate within the ganglion and inner nuclear layers in response to the initial injury within the host retina compared to controls. These findings suggested that SCSC have the potential for replacement therapy for a variety of eye diseases in adults (i.e. macular degeneration, retinal ganglion cell loss in glaucoma). This work was presented during the annual Association for Research in Vision and Ophthalmology (ARVO) meeting.

In 2005, Dr. Shareef joined the Flaum Eye Institute (FEI) at the University of Rochester School of Medicine, in Rochester N.Y. He conducted a literature search to determine the prevalence of drug induced secondary angle closure glaucoma (sACG) from medications that had a warning label for ‘glaucoma’. In four decades, anti-seizure, anti-depressants and bronchodilators were the most frequent drug class reported. Recommendations were made for physicians to take a good medical history to rule out a drug-induced etiology if patients present with bilateral sACG and to warn them of this risk prior to prescribing these classes of drugs. The findings were presented at the annual ARVO scientific meeting.

He also served as the study site principal investigator in an American Academy of Ophthalmology (AAO) sponsored prospective multi-center observational study comparing the effectiveness of treatment strategies utilized by glaucoma specialists in caring for patients with open angle glaucoma. At the invitation of a journal editor, He wrote a major review paper on the important role of intraoperative gonioscopy in the burgeoning field of micro-invasive glaucoma surgery (MIGS). This publication formed the basis for the proposal and acceptance of a two-hour instructional course by the American Academy of Ophthalmology. These efforts led to the creation of an educational website dedicated to teach this skill set.

This skill set empowered him to expand his surgical armamentarium beyond glaucoma and cataract surgery in becoming a complete anterior segment surgeon by performing iris repair, and traumatic cyclodialysis clefts using innovative techniques. Based upon this work, he has been invited annually at several national meetings as a guest speaker, panelist, moderator, course instructor and wet lab surgical instructor. These educational efforts and achievements have culminated in his promotion to the rank of professor at the University of Rochester School of Medicine in June 2018.

Clinical Interests

Dr. Shareef cares for a variety of glaucomas and has an interest in complex and high-risk cataract and glaucoma surgeries including MIGS. From a quality of life standpoint, Dr. Shareef became an early surgical adopter obtaining certification in several MIGS procedures in his quest to offer patients less invasive surgeries with quicker visual recovery.

Dr. Shareef’s clinical research interests focus on better understanding the outflow pathway and innovative ways in which it can be surgically modified in glaucoma patients to safely lower eye pressure while having minimal impact on their lives. Dr. Shareef looks forward to collaborating with glaucoma colleagues and researchers at UHEI in conducting clinical trials and contributing to the evolving field of MIGS surgery. As an educator and glaucoma fellowship director, he looks forward to training future glaucoma specialists who will continue to carry the torch of helping patients avert blindness while continuing to live productive lives.

His educational efforts have been nationally recognized. In the summer of 2019, he was the recipient of the AAO Achievement Award that “symbolizes your commitment to advancing the profession and positively impacting your patients eye health.” Additionally, Orbis, an international non-profit organization dedicated to saving sight worldwide solicited permission to use his published work for a glaucoma training course recently published on their website June 2019.

At the UH Eye Institute, Dr. Shareef sees patients at UH Eye Institute’s main campus as well as Landerbrook, Westlake, Parma and Hudson satellite clinics.

Other Notable Achievements

Dr. Shareef taught himself video editing and has produced several high-quality instructional surgical videos voted on by peers as the best presentation at national meetings including the American Glaucoma Society (AGS) in 2013 and the American Society of Cataract and Refractive Surgery (ASCRS) in 2018.

Along with an expert panel of colleagues, since 2015, he serves as the senior instructor for an instructional course offered at the annually at the AAO meeting teaching attendees the nuances of surgical gonioscopy and MIGS. He has been invited to contribute several book chapters and articles and serves as a reviewer for several leading ophthalmology journals.

He has also been invited as a visiting professor nationally at several institutions including Columbia University, New York Medical College, University of Pittsburgh Eye Institute and the Kellogg Eye Center. He has been a recurring invited speaker for the annual Northeast Pennsylvania Optometric Society Meeting. He has also presented internationally including Bilbao, Spain and the Kingdom of Saudi Arabia. He serves as a referee for several ophthalmology journals and has been invited to write several articles and book chapters by his peers.

Along with his spouse and children, Dr. Shareef spends time enjoying attending professional sporting events and all that Cleveland has to offer.

Office Locations

CMC Bolwell Ste 3200

11100 Euclid Ave
Cleveland OH, 44106

Landerbrook HC Ste 306

5850 Landerbrook Dr
Mayfield Heights OH, 44124

Parma Med Arts Ctr 2 Ste 100

6707 Powers Blvd
Parma OH, 44129

Westlake HC Bldg B Ste 102

950 Clague Rd
Westlake OH, 44145

Hudson HC Ste 104

5778 Darrow Rd
Hudson OH, 44236

Patient Experience Reviews

4.7 out of 5

128 Ratings

Patient Comments (31)

Reviewed On 6/1/2021
I had a very good experience with Dr. Shareef. ***

Reviewed On 6/1/2021
totally good experience

Reviewed On 6/1/2021
very polite, caring ,always letting me know what is going on.

Reviewed On 5/1/2021
This was my first visit with Dr.Shareef. He made me feel comfortable and explained my medical condition in a way that I could understand.

Reviewed On 5/1/2021
this provider was very good at answering my questions and explaining what he was doing

Reviewed On 5/1/2021
excellent doctor - communicates well and has a lot of patience.

Reviewed On 4/1/2021
Dr. Shareef is an outstanding doctor. I am lucky to have access to his care.Thanks to him my sight can be protected .

Reviewed On 4/1/2021
excellent experience

Reviewed On 4/1/2021
very good exchange with doctors and positive

Reviewed On 4/1/2021
All went smoothly and professional.

Reviewed On 4/1/2021
To me and for me Dr. Shareef is an excellent physician. He has been my eye doctor for about a year now. ***

Reviewed On 4/1/2021
Very good.

Reviewed On 3/1/2021
Very professional and kind, explained fully & didn't rushed. I'm so lucky to have found a doctor i have confidence in.

Reviewed On 2/1/2021

Reviewed On 2/1/2021
he. was knowledgeable and caring.

Reviewed On 1/1/2021
Dr. Shareef. was. knowledgeable. caring efficient. he put. my. mother. at. ease

Reviewed On 1/1/2021
They were extremely good

Reviewed On 12/1/2020
doctor Sharif is a great person

Reviewed On 12/1/2020
Dr Shareef explained the issue I am having with my eye in a way that I fully understood. He put my mind at ease.

Reviewed On 11/1/2020
Good visit with a great doctor!

Reviewed On 11/1/2020
first time and l was so impressed with this Doctor and l think she was a medical assistant who did some test before l saw the doctor, she was very nice and professional. The doctor explained everything and was kind of funny, he has a great personality.

Reviewed On 10/1/2020
Dr was running late but the care was excellent.

Reviewed On 10/1/2020
very helpful

Reviewed On 9/1/2020
love this doctor

Reviewed On 9/1/2020
provider did an outstanding job

Reviewed On 9/1/2020
Very Good

Reviewed On 9/1/2020

Reviewed On 9/1/2020
in a few words I word like to thank Dr Shareef for an excellent surgery and follow up appointment! He was the Greatest! Thank you, Dr Shareef!

Reviewed On 8/4/2020
my experience with Dr Shareef and his staff was excellent. my surgery procedure was so professional. I have had a very comfortable recovery due to the excellence of my surgeon!

Reviewed On 8/4/2020
*** good

Reviewed On 8/4/2020
No Complaints.Dr. and health care staff very professional/caring

Industry Relationships

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members’ ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UH’s policy (PDF) on practitioner-industry relationships.

As of December 31, 2016, Shakeel Shareef did not disclose any Outside Relationships with Industry.