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The Neurological Institute Journal incorporates articles about the learning and healing practices gained through collaboration with scientists at Case Western Reserve University School of Medicine and physicians at the University Hospitals Neurological Institute. Semi-annual contributions are made by some of the country’s foremost experts in neurology, neurosurgery, neuroradiology, neuro-oncology, neuro-ophthalmology, neurology, neuropathology, neuropsychology, neuropsychiatry and related specialties.

Full articles and associated free AMA PRA Category 1 Credits™ are available following the links below for each Journal. Credits will be recorded by the Case Western Reserve University School of Medicine CME Program. You may also request a printed copy of past publications.

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Volume 4 • Number 2 • Winter 2012

Mimicking Creutzfeldt-Jakob Disease: Identification of Treatable Conditions
By Numthip Chitravas, MD, Pierluigi Gambetti, MD, Richard S. Jung, MD, R. John Leigh, MD, Diane M. Kofskey, Mark L. Cohen, MD, and Janis E. Blevins

The prion protein is a membrane-anchored neuronal glyocoprotein of uncertain function but thought to be involved in long-term memory.1 Prion diseases are disorders of protein conformation, the most common of which in humans is Creutzfeldt-Jakob disease (CJD).

Anti-Myelin-Associated Glycoprotein Neuropathy: Borderland between Neurology and Hematology
By Pichet Termsarasab, MD, Prerna Malla, MBBS, Tanzila Shams, MD, and Bashar Katirji, MD

A 70-year-old man with a three-year history of progressive gait ataxia and numbness was referred to our Neuromuscular Center by his local neurologist for evaluation of possible Charcot-Marie- Tooth (CMT) disease.

Stereotactic Radiosurgery: Intracranial Tumors, Skull Base Tumors, and Benign Disorders
By Simon S. Lo, MD, Jonathan Miller, MD, Andrew E. Sloan, MD, FACS, Warren R. Selman, MD, S. Alan Hoffer, MD, and Mitchell Machtay, MD

For the past several decades, conventional fractionation has been the standard approach for radiotherapy. In the early 1950s, Swedish neurosurgeon Lars Leksell challenged the conventional wisdom of conventionally fractionated radiotherapy and pioneered the concept of stereotactic radiosurgery (SRS), entailing the delivery of a single high-focused dose of radiation to a tumor in a highly conformal fashion with very steep dose gradient. In the late 1960s, the first prototype of Gamma Knife machine was invented in Sweden.

Glioblastoma Multiforme Clinical Trial Studies 5-Aminolevulinic Acid for Fluorescence-Guided Resection
By David Dean, PhD, Nancy L. Oleinick, PhD, Brian C. Wilson, PhD, Mark L. Cohen, MD, Vaijayantee Belle, MBBS, MCh, DNB, Andrew E. Sloan, MD, FACS

Glioblastoma multiforme (GBM) is a devastating diagnosis, with a median survival of less than one year and less than 5 percent two-year survival. The past three decades have shown few advances in treatment. Several recent studies have demonstrated a clear link between completeness of tumor resection of malignant brain, quality of life, and survival.

New Neurological Applications for Botulinum Toxin
By Steven A. Gunzler, MD, and David E. Riley, MD

Botulinum toxin is a protein derived from the bacterium Clostridium botulinum. It irreversibly binds to the presynaptic receptor, is endocytosed, and then blocks acetylcholine release. Botulinum toxin generally exerts its clinical effects within one week and loses its benefit after approximately three months.

Read the full issue • CME Credits

Previous Issues

Spring 2011 • Volume 4 • Number 1
CME credits are no longer available

When Close Enough Isn’t Close Enough: Dual Stereotaxy for Placement of Epilepsy Monitoring Electrodes
Advances in Anterior Skull Base Surgery
Spasticity Treatment in Children
Expanding the Spectrum of Indications for Epilepsy Surgery in Children
The Neuropsychology of Sports-Related Concussion: Return-to-Play and the Management of Head Injury in Athletes

Winter 2010 – Volume 3 • Number 2
CME credits are no longer available

Carotid Endarterectomy versus Carotid Artery Stenting: Which is the Best Choice for Your Patient? (An Editorial)
Treatment Options for Carotid Artery Occlusive Disease: Carotid Endarterectomy Versus Carotid Stenting
Managing Intracranial Aneurysms: Surgical Clipping or Endovascular Coiling?
Development of the UH Stroke and Cerebrovascular Center
Sudden Unexpected Death in Epilepsy