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In this Section
For information or to register for screening in a selected trial, call HealthMatch (216) 844-5000
How to enroll
Search the listing of clinical trials below. When you find one which is appropriate for you click more information and you can apply by contacting us directly by phone or by online application form.
Clinical Trials

A Clinical Trial is a research study to answer specific questions about new therapies or new ways of using established treatments. Clinical Trials are used to determine whether new drugs or treatments are both safe and effective. Most current drug therapies were initially developed in past Clinical Trials.

Participants include men, women and children of all ages, races, religions and ethnic backgrounds, depending on the study guidelines. Protection of the rights, safety and welfare of our research participants is always our primary concern. Clinical Trial participants are seen regularly by the research staff to monitor their health and to determine the safety and effectiveness of their treatment. Each Clinical Trial is approved by the Institutional Review Board consisting of healthcare professionals as well as lay people from the community to ensure that risks are monitored and federal regulations are followed.

What follows is a brochure of some of the hundreds of Clinical Trials at University Hospitals of Cleveland that are actively recruiting participants. If you would like to participate, please note that each trial is listed with study-specific contact information. You may also enroll online by selecting the "Enroll in Clinical Trials" link at the left of this screen.

We hope you find this brochure useful, and that you will share it with friends and family who may benefit from one of the studies.

Nathan Levitan, MD
Chief Medical Officer
University Hospitals of Cleveland
Find a Clinical Trial
Trial Name:

ACNS 0423
Intro: A Phase II Study of Concurrent Radiation and Temozolomide Followed by Temozolomide and Lomustine (CCNU) in the Treatment of Children with High Grade Glioma
Condition:
Description: This study will determine if treatment with temozolomide and radiation, followed by treatment with a combination of temzolomide and Lomustine (CCNU) for 9 months after radiation therapy, works better than the standard treatment in children with a type of brain tumor called a high-grade glioma. In the first part of the treatment, radiation therapy will be directed to the brain, 5 days a week for 6 weeks. Patients will be given the drug Temozolomide by mouth for 42 days (6 weeks). A four-week rest period will follow. The second part of the treatment, called Maintenance, begins at the end of the rest period. No further radiation will be given but the drug Temozolomide will be given by mouth for five days in a row followed by a 37 day break. Another chemotherapy drug known as Lomustine (CCNU) will also be given by mouth along with the temzolomide on day 1. This 42-day cycle will be repeated 6 times. Overall, the treatment portion of the study will last for about 11-12 months.
Criteria: 1. Must have newly diagnosed CNS tumor: anaplastic astrocytoma, glioblastoma multiforme or gliosarcoma, with histological verification of disease 2. Must begin therapy within 31 days of surgery 3. Must have a pre-operative and post-operative brain MRI with and without contrast (requirement for post-operative MRI is waived for patients who undergo biopsy only) 4. Must be 3 years of age or older but less than 22 years of age at time of enrollment 5. Cannot have received any prior treatment other than surgery or corticosteroids 6. Must have adequate bone marrow, kidney, liver and CNS function if seizures are well controlled 7. Must be able to swallow medications 8. Must have performance level of ≥ 50% (Karnofsky) for patients > 16 years of age, and ≥ 50 (Lansky) for patients ≤ 16 years of age Must have life expectancy eight weeks or greater
Contact: For Cancer Information, Current Clinical Trials, and Referral to a Physician please call (216) 844-5432 or (800) 641-2422

Participant Confidentiality:

All information regarding participation in Clinical Trials is treated with the utmost confidentiality. University Hospitals Case Medical Center and the Division of Clinical Research recognize and respect the confidentiality of this information. Access to information related to clinical trials and their participants is restricted to authorized clinical trials personnel only.

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