Retinal Diseases Image Analysis Reading Center

Retinal Diseases Image Analysis Reading Center (REDIARC) was founded in 1999 by Dr. Suber S. Huang. The primary function of REDIARC is to evaluate the pathology of fundus photographs, fluorescein angiograms, or other retinal imaging modalities for prospective clinical trials, including evaluation of fundus photographs and fluorescein angiograms, certification of photographers and clinical sites, and analysis of study results. REDIARC is located on the University Hospitals Case Medical Center (UH CMC) campus, next to the Case Western Reserve University (CWRU) campus, and is comprised of employees that are employed through either the hospital or university.

Efforts of the center are directed through the Principal Investigator, Suber S. Huang, MD, MBA, in conjunction with the Technical Director, Beth Ann Benetz, MA, CRA, FOPS. REDIARC is governed by the University Hospitals Institutional Review Board (IRB), which is fully accredited by AAHRPP, and is located in Lakeside building, Room 1400 on the UHCMC campus. Staff follows the regulations set forth by Good Clinical Practices (GCP), International Conference on Harmonization (ICH), Department of Health and Human Services (DHHS), and Food and Drug Administration (FDA) regulations.

REDIARC is an experienced Reading Center that has analyzed images for over 2500 patients, totaling more than 8000 study visits in the past 10 years. In the course of those studies, REDIARC has certified more than 425 clinical sites and their photographers in 23 countries around the world.

REDIARC has expertise in trials studying:

  • Geographic atrophy in advanced (non-neovascular) AMD.
  • Neovascular AMD.
  • Non-infectious uveitic cystoid macular edema.
  • Non-proliferative diabetic retinopathy.
  • Diabetic macular edema.
  • Retinitis pigmentosa.
  • Retinal vascular changes in Alzheimer’s disease.
  • Effects of severe altitude on the retina.


  • Provided advice on analysis, interpretation, and reporting of Fundus Photographic and Retinal Angiography images.
  • Developed standardized grading protocols.
  • Collected film and digital imaging data from study sites.
  • Graded study images.
  • Entered numerical and qualitative data into a computerized database.
  • Provided the data and reading results to clinical trial organizations, which use this analysis as part of their assessment of treatment effect or disease progression.

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