Harrington Grant Application Policies
Eligibility Criteria for Applicants
Harrington Discovery Institute requires that all applicants meet the following criteria:
- Hold an MD or MD/PhD from an accredited institution
- Hold a faculty position at an accredited academic medical center, university or research institution in the U.S. and conduct the majority of his/her research activities at that institution
- A project may have only a single Principal Investigator (PI) who will be responsible for project oversight and financial management. The PI may engage collaborators, core labs, or commercial CROs to execute any fraction of the project.
- Past recipients of HDI Scholar-Innovator awards may submit new and distinct proposals but may not seek additional support for previously funded projects
Sponsoring Institution Requirements
Investigators may apply from accredited academic medical centers, research institutions or universities in the U.S. and U.S. territories. Institutions must provide the necessary facilities and infrastructure for the research, and accept the conditions of the Grant, including the Budget & Use of Funds. They must assure compliance with the prevailing national guidelines for animal and human studies and provide proper oversight of the Grant funds.
Sponsoring institutions must safeguard the rights and welfare of individuals who participate as subjects in research activities by reviewing proposed activities through an Institutional Review Board (IRB) as specified by the U.S. Department of Health and Human Services Office for Human Research Protections, HHS OHRP. Additionally, the Grantee’s institution must assure appropriate governance of animal studies. IRB approval and IACUC numbers are not required at the time of application, but must be provided for final signature of the Grant Agreement, which will be sent to Grantees shortly after they have been selected.
Additionally, sponsoring institutions must adhere to current U.S. Department of Health and Human Services guidelines regarding financial conflict of interest, recombinant DNA, and research misconduct.
Harrington Scholar-Innovator Project Types
The goal of the Harrington Scholar-Innovator Grant Program is to advance physician-scientist-initiated projects aimed at clinical introduction of new medicines (drugs or biologics). The specific focus of eligible projects includes fundamental discovery (elucidation of novel targets), novel drugs and biologics or drug-device combinations.
The Harrington Grant Application Submission and Selection Process
The 2015 Harrington Scholar-Innovators will be selected by a two-stage process. Interested applicants are asked to submit a Letter of Intent by 5:00 PM EDT May 2, 2014 Invitations to submit a full proposal will be sent to applicants via email mid-late June 2014, and proposals will be due on August 15, 2014.
Confidentiality in the Application Process
As a part of The Harrington Project, members of Harrington Discovery Institute’s review panel and Scientific Advisory Board are required to complete mutual Confidentiality & Disclosure Agreements with Harrington Discovery Institute.
Non-public applicant information is always kept confidential (and limited in distribution to the reviewers and Harrington Discovery Institute administrative team). The abstract summary, including the applicant’s name and institutional affiliation, for those selected as Scholar-Innovators, may be used by Harrington Discovery Institute for publicity and marketing purposes (on the Harrington Discovery Institute website, news releases, etc.) at Harrington Discovery Institute's sole discretion.
Applicants acknowledge that University Hospitals Health System may conduct research that is related to or competitive with proposals submitted by applicants, but University Hospitals Health System commits not to use information submitted by applications in connection with such research.
The Harrington Scholar-Innovator Grant Review Panel
The review panel will consist of subject matter experts with specialized scientific expertise in the area(s) designated in the application, as well as seasoned professionals with expertise in drug discovery and commercialization.
The review panel will score each application on a variety of criteria, including but not limited to:
- Quality of science
- Medical need
- Clinical impact
The Scientific Advisory Board at Harrington Discovery Institute will make the final selections of grant winners. Applicants who fail to fill out their applications by the deadline and/or in accordance with the detailed application instructions are subject to disqualification at the outset of the review period or any time during the review period.
Letters of Intent will be reviewed and the Harrington Discovery Institute will select those projects which have the greatest clinical potential, as well as demonstrate a highly innovative approach to significant clinical problems.
The Harrington Discovery Institute will subsequently invite selected PIs to submit a full proposal. Notices will be sent in mid-late June 2014 and full proposals will be due on August 1, 2014. Barring any unforeseen delays, final selection of winners will be in November and the effective date of this grant will be January 1, 2015.
Comments from Review Committee
Harrington Discovery Institute is unable to provide reviewers’ comments on Letters of Intent or applications.
Timeline & Grant Agreement
Selection committee results, including winners and those rejected, are released in November. Winners of the grant must be prepared to sign the Grant Agreement in December.
The Grant start date is January 1 and runs on a calendar year basis.
Annual Scientific Symposium Builds a National Network of Physician-Scientists
Part of Harrington Discovery Institute’s mission is to build a broad connected community of physician-scientist-innovators. Harrington Discovery Institute will hold an annual symposium that current Grantees are required to attend.
The Symposium, held in late spring at University Hospitals Case Medical Center in Cleveland, Ohio, will bring together Harrington Scholar-Innovators, members of the Innovation Support Center, drug development experts, members of the Scientific Advisory Board, and other national physician-scientist leadership. Grantees are expected to present their project and findings-to-date. A stipend for travel and lodging will be provided by Harrington Discovery Institute, subject to the terms of the Grant Agreement.
Harrington Discovery Institute will provide up to 10 new awards each year. Awards will include:
- A “base” grant amount of $100,000 over two years
- Additional funding according to the needs of your specific project
- Direct strategic/project management support through ours Innovation Support Center. Investigators will also receive drug discovery support and related resources through the Innovation Support Center (ISC), including:
- Consulting services from highly experienced drug development personnel
- Business and commercialization advice
- Clinical development advice
- Regulatory assistance
- IP review and advice
- Assistance identifying and securing additional financial support based on the needs of the project
The Harrington Discovery Institute and ISC team will work closely with the awardee and their affiliated institution to maximize the clinical and commercial potential of selected projects.
Use of Harrington Scholar-Innovator Grant Funds
General: No more than $10,000 of the total grant can be used for capital expenditures or equipment. The award may only be used for direct project expenses, not for institutional overhead.
Salary: The award may be used to cover salaries for post-docs equivalent to the % effort devoted to the project. Please note that PI's salary is limited to 10% of the total award amount.
Travel: The award may not be used for travel, meetings, professional fees, publication fees, etc.
Harrington Project Intellectual Property Guidelines
Harrington Discovery Institute does not claim any rights whatsoever to patents, copyrights or trademarks to other intellectual property created as a result of work sponsored by Scholar-Innovator Grants (“Intellectual Property”).
On all aspects of Intellectual Property, Principal Investigators are encouraged to confer with their technology transfer office and/or office of sponsored programs for guidance. Harrington Scholar-Innovators may seek input and advice on patent protection, including ways to strengthen intellectual property, from the Innovation Support Center, which also claims no rights whatsoever to IP.
Grantees should take measures to ensure protection of any Intellectual Property in accord with Federal and institutional requirements.
NIH Data Sharing Policy
Scientific research depends on the free flow of information and ideas. A data-sharing plan is not requested or required. However, in its annual evaluation of progress as outlined in the Scientific Reporting & Review of Progress section below, Harrington Discovery Institute will consider, as part of the criteria for continued funding, adequate progress in sharing unique research resources developed with funds from the Grant, as well as a demonstrated willingness to make research resources developed during the project widely available to the research community.
In accordance with a mission to advance research and accelerate the development of new therapeutics, the HDI encourages compliance with the National Institutes of Health (NIH) data sharing policy. Unique research resources (developed with funds from the Grant should be made available to the research community according to NIH guidelines. Grantees may distribute reagents and data without HDI approval in compliance with the norms and rules of their institution.
Scientific Reporting & Review of Progress
Yearly renewal of the Grant is dependent on timely submission of a written progress report, as well as attendance at the annual Scientific Symposium.
The progress report should be approximately one (not exceeding two) pages and should cover findings to-date, status, and future direction. It should also include a one page financial report accounting for expenditures during the prior period and an updated budget (if applicable).
The report is due on November 15th each year.
Changes to Project Scope
A significant change in the project scope or work should be discussed with Harrington Discovery Institute’s Director and approved in writing or by email by the Director.
Grants may be transferred to another institution that agrees to assume the Policies, Terms & Conditions of the Grant. Permission to transfer a Grant to another institution must be obtained from Harrington Discovery Institute’s Director.
Compliance and Administrative Matters
Grants are funded by Harrington Discovery Institute, after the recommendations of the Scientific Advisory Board. Harrington Discovery Institute Staff will assure compliance with Grant policies and will be responsible for all administrative matters.
The Principal Investigator and his or her institution are solely responsible for execution of the project, including compliance with all relevant Federal and State laws and guidelines.
Harrington Discovery Institute reserves the right to refine and amend policies as required.
For Questions or More Information
Harrington Discovery Institute will respond to all questions about the application process or the grant program. For all questions, please contact us via email at hdiquestions@HarringtonDiscovery.org.