Robert Bonomo, MD
Robert Bonomo, MD is Professor of Medicine, Pharmacology, Molecular Biology, and Microbiology at Case Western Reserve University, Chief of Medical Service at the Louis Stokes Cleveland Department of Veteran Affairs Medical Center, and the Vice Chair for Veteran Affairs, Department of Medicine, at University Hospitals Cleveland Medical Center.
Dr. Bonomo’s research interest is the structure-function relationships and the mechanistic basis of resistance to β-lactamase inhibitors, the molecular epidemiology of multidrug resistant gram negative bacteria, and the implementation of molecular diagnostics in clinical care of patients with infectious diseases.
Presently, new β-lactamase inhibitors (BLIs) are urgently needed to combat the threat of multidrug resistance (MDR) in Gram-negative bacteria (GNB). Boronic acid transition state inhibitors (BATSIs) are competitive, reversible BLIs that offer real promise as novel therapeutic agents.
Incorporating the boronic acid scaffold and using click chemistry, they designed potent class A and C β-lactamase inhibitors effective against β-lactamases of the highest clinical importance and showed antimicrobial activity against laboratory and clinical strains.
Dr. Bonomo received his BA from Hamilton College and his MD from Case Western Reserve University before his residency in internal medicine and fellowship in infectious disease at University Hospitals of Cleveland. He is an elected member of the American Academy of Microbiology and the Association of American Physicians. He is also Co-Director of the Laboratory Center of the Antibacterial Resistance Leadership Group (ARLG).