Marikki Laiho, MD, PHD
Marikki Laiho, MD, PhD is Willard and Lillian Hackerman Professor in Radiation Oncology and Professor of Radiation Oncology and Oncology at the Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine, Baltimore, MD.
At Johns Hopkins, Dr. Laiho is the Director of Division of Molecular Radiation Sciences, a research division that focuses on the basic mechanistic aspects of cellular responses to genetic lesions and which strives towards translating this information to improved cancer therapies.
Cancers have altered transcriptional programs that lead to deregulation of normal cellular functions and support cancer cell characteristics. These processes are governed by RNA polymerase I (Pol I), which is highly responsive to external stimuli and commonly hyperactivated in cancer.
Dr. Laiho’s project with the Harrington Discovery Institute examines the impact of controlling of Pol I and explores cancer cell vulnerabilities to mitigate Pol I deregulation. Dr. Laiho and her lab will introduce a novel small molecule compound (BMH-21) that targets Pol I activity as a new, highly potential cancer therapeutic candidate.
Dr. Laiho received her MD and PhD from the University of Helsinki, and conducted her postdoctoral fellowships at the University of Massachusetts Medical Center, Worcester, MA, and the Sloan-Kettering Institute, New York, NY.