Rahul Kohli, MD, PhD
University of Pennsylvania, Philadelphia, Pa.
Dr. Kohli’s research is developing a drug that could increase bacteria sensitivity to existing antibiotics or slow or prevent the development of antibiotic resistance.
Rahul Kohli, MD, PhD, is Assistant Professor, Division of Infectious Disease, Departments of Medicine and Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa.
Dr. Kohli and his laboratory aim to target the pathways by which pathogens develop resistance to antimicrobials. The Kohli laboratory broadly focuses on DNA-modifying enzymes and pathways, particularly those that contribute to genomic plasticity. The team utilizes a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study the fundamental question of how a genomic diversity arises in nature.
In bacteria, adaptation and evolution are closely linked to the stress response of the SOS pathway. The SOS pathway can be triggered by numerous stressors, including antibiotics, and the net result is accelerated acquisition of drug resistance. The team is working to characterize the key regulatory and effector enzymes from the SOS pathway and to target the pathway as a means to combat antibiotic resistance.
The Kohli laboratory aims to understand these pathways of purposeful DNA modification and mutation. Additionally, the team applies chemical biology to decipher and target these pathways, to impede the development of multidrug-resistance in pathogens or prevent the neoplastic transformations that can result from genomic mutation.
Dr. Kohli earned his medical degree and his doctorate in Biochemistry and Molecular Pharmacology at Harvard Medical School, Boston.